Shim Hyoeun, Park Boram, Shin Hye-Jin, Joo Jungnam, Yoon Kyong-Ah, Kim Young Min, Hayashi Tomonori, Tokunaga Katsushi, Kong Sun-Young, Kim Joo-Young
Department of Laboratory Medicine, National Cancer Center, Goyang, Republic of Korea.
Biometrics Research Branch, National Cancer Center, Goyang, Republic of Korea.
Hum Immunol. 2019 Feb;80(2):107-111. doi: 10.1016/j.humimm.2018.10.013. Epub 2018 Oct 21.
Human leukocyte antigen (HLA) class II alleles have been previously associated with cervical cancer. However, these associations vary widely across racial and ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on cervical cancer in a Korean population. HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles were analyzed in 457 cervical cancer patients and compared to those of 926 control subjects. The odds ratio (OR) of each allele between the patients and controls was calculated using the logistic regression model. Patients, had significantly lower frequencies of HLA-DRB1 and HLA-DQB1 alleles than control subjects: HLA-DRB113:02:01 (4.4% vs 8.8%; OR 0.48, 95% confidence interval (CI) 0.27-0.84; p = 0.001), HLA-DRB104:06 (2.1% vs 4.7%; OR 0.44, 95% CI 0.20-0.97; p = 0.033), and HLA-DQB106:04:01 (2.3% vs 5.0%; OR 0.46, 95% CI 0.22-0.94; p = 0.021). No significant association was observed for HLA-DQA1. Protective associations between HLA-DRB113:02, HLA-DRB104:06, and HLA-DQB106:04 alleles and cervical cancer were found in the Korean population.
人类白细胞抗原（HLA）II类等位基因先前已被证实与宫颈癌有关。然而，这些关联在不同种族和族裔群体中差异很大。因此，我们评估了HLA II类等位基因对韩国人群宫颈癌的影响。对457例宫颈癌患者的HLA-DRB1、HLA-DQB1和HLA-DQA1等位基因进行了分析，并与926例对照受试者的等位基因进行了比较。使用逻辑回归模型计算患者和对照之间每个等位基因的优势比（OR）。患者的HLA-DRB1和HLA-DQB1等位基因频率显著低于对照受试者：HLA-DRB113:02:01（4.4%对8.8%；OR 0.48，95%置信区间（CI）0.27 - 0.84；p = 0.001），HLA-DRB104:06（2.1%对4.7%；OR 0.44，95%CI 0.20 - 0.97；p = 0.033），以及HLA-DQB106:04:01（2.3%对5.0%；OR 0.46，95%CI 0.22 - 0.94；p = 0.021）。未观察到HLA-DQA1有显著关联。在韩国人群中发现HLA-DRB113:02、HLA-DRB104:06和HLA-DQB106:04等位基因与宫颈癌之间存在保护性关联。
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