Neurology Department, Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Toulouse Neuro-Imaging, Inserm, UPS, Université de Toulouse, Toulouse, France.
Curr Neurol Neurosci Rep. 2018 Oct 23;18(12):100. doi: 10.1007/s11910-018-0904-9.
The interest in SSRIs after stroke has increased in the past few years, with better knowledge of post-stroke depression and with the demonstrated capacity of some SSRIs to act on the functional recovery of non-depressed subjects.
Arguments for the action of SSRIs in favour of post-stroke neurological function recovery have improved through new elements: basic science and preclinical data, positive clinical trials and repeated series of stroke patient meta-analysis, and confirmation of favourable safety conditions in post-stroke patients. Global coherence is appearing, showing that SSRIs improve stroke recovery in non-depressed patients when given for 3 months after the stroke, with highly favourable safety conditions and a favourable benefit/risk ratio. Large series are still needed.
近年来，人们对卒中后 SSRI 的兴趣日益增加，这是由于对卒中后抑郁有了更好的认识，并且一些 SSRI 已被证实能够促进非抑郁患者的功能恢复。
通过新的元素，SSRI 作用于改善卒中后神经功能恢复的观点得到了进一步证实：基础科学和临床前数据、阳性临床试验以及对卒中患者的多次系列荟萃分析，并且确认了卒中患者的有利安全条件。现在开始出现整体一致性，表明 SSRI 可改善非抑郁患者卒中后 3 个月的恢复，具有高度有利的安全性和良好的获益/风险比。仍需要大量的研究。
