Vedyasova O A, Kovaleva T E
Department of Human and Animal Physiology, S. P. Korolev Samara National Research University, Samara, Russia.
Bull Exp Biol Med. 2018 Oct;165(6):711-714. doi: 10.1007/s10517-018-4248-x. Epub 2018 Oct 23.
The role of GABAergic inhibition in the regulation of activity of the parafacial respiratory group was studied on narcotized mature rats. Microinjections of GABA agonist muscimol into the parafacial respiratory group inhibited external respiration and bioelectrical activity of the diaphragmatic muscle resulting in diminished tidal volume and decreased respiration rate accompanied by prolonged inspiration, expiration, and intervals between the inspiratory bursts in the phrenic electromyogram. In contrast, microinjections of GABA antagonist bicuculline into this group stimulated respiration and markedly increased its volumetric parameters. In addition, blockade of GABA receptors affected the expiratory phase and interburst intervals in the phrenic electromyogram, but produced no effect on respiration rate. These findings attested to contribution of GABA-mediated inhibition into the performance of parafacial respiratory group. The study revealed different roles of GABA receptors in modulation of the mechanisms of respiration rate control in mature rats and formation of inspiratory motor outputs originating from the parafacial respiratory group.
在麻醉的成年大鼠身上研究了γ-氨基丁酸（GABA）能抑制在调节面神经旁呼吸组活动中的作用。向面神经旁呼吸组微量注射GABA激动剂蝇蕈醇可抑制外部呼吸和膈肌的生物电活动，导致潮气量减小、呼吸频率降低，同时伴有膈神经肌电图中吸气延长、呼气延长以及吸气爆发之间的间隔延长。相反，向该组微量注射GABA拮抗剂荷包牡丹碱可刺激呼吸并显著增加其容积参数。此外，GABA受体的阻断影响了膈神经肌电图中的呼气阶段和爆发间期，但对呼吸频率没有影响。这些发现证明了GABA介导的抑制对面神经旁呼吸组功能的贡献。该研究揭示了GABA受体在调节成年大鼠呼吸频率控制机制以及源自面神经旁呼吸组的吸气运动输出形成中的不同作用。
