大鼠海马体中的γ-氨基丁酸能神经末梢拥有调节γ-氨基丁酸释放的α2肾上腺素能受体。
GABAergic nerve terminals in rat hippocampus possess alpha 2-adrenoceptors regulating GABA release.
作者信息
Pittaluga A, Raiteri M
出版信息
Neurosci Lett. 1987 May 19;76(3):363-7. doi: 10.1016/0304-3940(87)90430-7.
PMID:3035440
Abstract
Noradrenaline enhanced in a concentration-dependent way the basal release of endogenous GABA from superfused rat hippocampus synaptosomes. The alpha 2-adrenoceptor antagonist yohimbine prevented the releasing effect of noradrenaline while the alpha 1-adrenoceptor antagonist prazosin was ineffective. It is concluded that GABAergic nerve terminals in rat hippocampus possess adrenoceptors of the alpha 2-subtype whose activation causes enhancement of GABA release.
摘要
去甲肾上腺素以浓度依赖的方式增强了从经超灌流的大鼠海马突触体释放内源性γ-氨基丁酸（GABA）的基础水平。α2-肾上腺素能受体拮抗剂育亨宾可阻止去甲肾上腺素的释放作用，而α1-肾上腺素能受体拮抗剂哌唑嗪则无效。由此得出结论，大鼠海马中的GABA能神经末梢具有α2亚型的肾上腺素能受体，其激活会导致GABA释放增加。
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