Chrm3 Gene and M3 Muscarinic Receptors Contribute to Salt-Sensitive Hypertension.
作者信息
Cowley Allen W
机构信息
From the Department of Physiology, Medical College of Wisconsin, Milwaukee.
出版信息
Hypertension. 2018 Sep;72(3):588-591. doi: 10.1161/HYPERTENSIONAHA.118.11494.
Abstract
摘要
相似文献
1
Chrm3 Gene and M3 Muscarinic Receptors Contribute to Salt-Sensitive Hypertension.Chrm3基因和M3毒蕈碱受体与盐敏感性高血压有关。
Hypertension. 2018 Sep;72(3):588-591. doi: 10.1161/HYPERTENSIONAHA.118.11494.
2
The use of a modified [3H]4-DAMP radioligand binding assay with increased selectivity for muscarinic M3 receptor shows that cortical CHRM3 levels are not altered in mood disorders.使用改良的 [3H]4-DAMP 放射性配体结合测定法，提高了对毒蕈碱 M3 受体的选择性，结果表明情绪障碍患者皮质 CHRM3 水平没有改变。
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 2;47:7-12. doi: 10.1016/j.pnpbp.2013.08.001. Epub 2013 Aug 17.
3
Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.M3 受体基因变异与盐敏感性、血压纵向变化及中国成年人高血压发病的关联。
J Clin Hypertens (Greenwich). 2024 Jan;26(1):36-46. doi: 10.1111/jch.14753. Epub 2023 Nov 27.
4
Influence of monovalent cations on the binding of a charged and an uncharged ('carbo'-)muscarinic antagonist to muscarinic receptors.单价阳离子对一种带电荷和一种不带电荷（“碳环”）的毒蕈碱拮抗剂与毒蕈碱受体结合的影响。
Br J Pharmacol. 1996 Mar;117(5):955-61. doi: 10.1111/j.1476-5381.1996.tb15287.x.
5
Muscarinic acetylcholine receptor 3 is dominant in myopia progression.毒蕈碱型乙酰胆碱受体 3 在近视进展中占主导地位。
Invest Ophthalmol Vis Sci. 2012 Sep 21;53(10):6519-25. doi: 10.1167/iovs.11-9031.
6
Novel Pathogenesis of Hypertension and Diastolic Dysfunction Caused by M3R (Muscarinic Cholinergic 3 Receptor) Signaling.由 M3R（毒蕈碱型乙酰胆碱受体 3）信号引起的高血压和舒张功能障碍的新发病机制。
Hypertension. 2018 Sep;72(3):755-764. doi: 10.1161/HYPERTENSIONAHA.118.11385.
7
Relative amounts of mRNA encoding four subtypes of muscarinic receptors (m2-m5) in human peripheral blood mononuclear cells.人类外周血单核细胞中编码毒蕈碱受体四种亚型（m2 - m5）的mRNA的相对含量。
J Neuroimmunol. 1999 Jun 1;97(1-2):191-5. doi: 10.1016/s0165-5728(99)00061-2.
8
Effect of continuous administration of a cholinergic agonist on [3H]4-DAMP binding and m3 mRNA expression in cultured human ciliary muscle cells.持续给予胆碱能激动剂对培养的人睫状肌细胞中[3H]4-DAMP结合及m3 mRNA表达的影响。
J Ocul Pharmacol Ther. 1999 Apr;15(2):153-63. doi: 10.1089/jop.1999.15.153.
9
Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain.假定磷酸化结构域对毒蕈碱型M1和M3受体的差异调节
Eur J Pharmacol. 1999 Jul 14;377(1):137-46. doi: 10.1016/s0014-2999(99)00303-9.
10
Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor.M3毒蕈碱型胆碱能受体介导的人结肠癌细胞增殖
Clin Cancer Res. 1999 Sep;5(9):2532-9.
引用本文的文献
1
Modularized Genes in an Adrenal Pathway Reveal a Novel Mechanism in Hypertension Pathogenesis.肾上腺途径中的模块化基因揭示了高血压发病机制的新机制。
Int J Mol Sci. 2025 Apr 17;26(8):3782. doi: 10.3390/ijms26083782.
2
Labels as a feature: Network homophily for systematically annotating human GPCR drug-target interactions.作为一种特征的标签：用于系统注释人类GPCR药物-靶点相互作用的网络同质性
Nat Commun. 2025 May 3;16(1):4121. doi: 10.1038/s41467-025-59418-6.
3
An organotypic atlas of human vascular cells.人类血管细胞的器官型图谱。
Nat Med. 2024 Dec;30(12):3468-3481. doi: 10.1038/s41591-024-03376-x. Epub 2024 Nov 20.
4
Genetics of Normotension Preventing Hypertension Leads to a Novel Physiological Paradigm.正常血压预防高血压的遗传学导致一种新的生理范式。
Rev Cardiovasc Med. 2022 Apr 1;23(4):119. doi: 10.31083/j.rcm2304119. eCollection 2022 Apr.
5
Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.M3 受体基因变异与盐敏感性、血压纵向变化及中国成年人高血压发病的关联。
J Clin Hypertens (Greenwich). 2024 Jan;26(1):36-46. doi: 10.1111/jch.14753. Epub 2023 Nov 27.
6
Shifting Paradigm from Gene Expressions to Pathways Reveals Physiological Mechanisms in Blood Pressure Control in Causation.从基因表达到途径的转变揭示了因果关系中血压控制的生理机制。
Int J Mol Sci. 2023 Jan 9;24(2):1262. doi: 10.3390/ijms24021262.
7
Conserved mammalian modularity of quantitative trait loci revealed human functional orthologs in blood pressure control.保守的哺乳动物数量性状基因座的模块性揭示了人类血压控制中的功能同源物。
PLoS One. 2020 Jul 23;15(7):e0235756. doi: 10.1371/journal.pone.0235756. eCollection 2020.
8
Whole-genome scanning for the heat-resistance-associated genes in the Droughtmaster breed ().对抗旱王牛品种中与耐热性相关基因进行全基因组扫描（）。
3 Biotech. 2019 Mar;9(3):95. doi: 10.1007/s13205-019-1620-0. Epub 2019 Feb 19.
本文引用的文献
1
MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension.肾中的 microRNA-214-3p 有助于高血压的发展。
J Am Soc Nephrol. 2018 Oct;29(10):2518-2528. doi: 10.1681/ASN.2018020117. Epub 2018 Jul 26.
2
Digestion-ligation-only Hi-C is an efficient and cost-effective method for chromosome conformation capture.仅消化连接的 Hi-C 是一种高效且具有成本效益的染色体构象捕获方法。
Nat Genet. 2018 May;50(5):754-763. doi: 10.1038/s41588-018-0111-2. Epub 2018 Apr 26.
3
Genome-wide map of proximity linkage to renin proximal promoter in rat.大鼠肾素近端启动子附近连锁的全基因组图谱。
Physiol Genomics. 2018 May 1;50(5):323-331. doi: 10.1152/physiolgenomics.00132.2017. Epub 2018 Mar 9.
4
Recent evidence that TADs and chromatin loops are dynamic structures.最近的证据表明 TADs 和染色质环是动态结构。
Nucleus. 2018 Jan 1;9(1):20-32. doi: 10.1080/19491034.2017.1389365. Epub 2017 Dec 14.
5
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.全基因组关联分析确定了新的血压基因座，并为心血管风险提供了生物学见解。
Nat Genet. 2017 Mar;49(3):403-415. doi: 10.1038/ng.3768. Epub 2017 Jan 30.
6
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.来自342415名个体关联研究的血压调节及其靶器官遗传学。
Nat Genet. 2016 Oct;48(10):1171-1184. doi: 10.1038/ng.3667. Epub 2016 Sep 12.
7
Blood Pressure Genetics Just Don't Add Up.血压遗传学就是无法说得通。
Circ Cardiovasc Genet. 2015 Aug;8(4):541-3. doi: 10.1161/CIRCGENETICS.115.001188.
8
Genetic and molecular aspects of hypertension.高血压的遗传与分子基础。
Circ Res. 2015 Mar 13;116(6):937-59. doi: 10.1161/CIRCRESAHA.116.303647.
9
Systematic Discovery of Human Gene Function and Principles of Modular Organization through Phylogenetic Profiling.通过系统发育谱法对人类基因功能和模块化组织原理进行系统性发现。
Cell Rep. 2015 Feb 17;10(6):993-1006. doi: 10.1016/j.celrep.2015.01.025. Epub 2015 Feb 12.
10
Dr Lewis Kitchener Dahl, the Dahl rats, and the "inconvenient truth" about the genetics of hypertension.刘易斯·基奇纳·达尔博士、达尔大鼠以及高血压遗传学的“难以忽视的真相”
Hypertension. 2015 May;65(5):963-9. doi: 10.1161/HYPERTENSIONAHA.114.04368. Epub 2015 Feb 2.
Zotero 插件