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儿童结核病服务的去中心化增加了乌干达的病例发现和预防性治疗的接受率。

Decentralisation of child tuberculosis services increases case finding and uptake of preventive therapy in Uganda.

机构信息

International Union Against Tuberculosis and Lung Disease, Paris, France;, The Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala.

International Union Against Tuberculosis and Lung Disease, Paris, France.

出版信息

Int J Tuberc Lung Dis. 2018 Nov 1;22(11):1314-1321. doi: 10.5588/ijtld.18.0025.

Abstract

BACKGROUND

A lack of capacity to diagnose tuberculosis (TB) in children at peripheral health facilities and limited contact screening and management contribute to low case finding in TB-endemic settings.

OBJECTIVE

To evaluate the implementation of a pilot project that strengthened diagnosis, treatment and prevention of child TB at peripheral health facilities in Uganda.

METHODS

In June 2015, health care workers at peripheral health facilities were trained to diagnose and treat child TB. Community health care workers were trained to screen household TB contacts. Before-and-after analysis as well as comparisons with non-intervention districts were used to evaluate impact on caseload and treatment outcomes.

RESULTS

By December 2016, the average number of children (age < 15 years) diagnosed with TB increased from 45 to 108 per quarter. The proportion of child TB among all TB cases increased from 8.8% to 15%, and the proportion completing treatment increased from 65% to 82%. Of 2270 child TB contacts screened, 55 (2.4%) were diagnosed with TB. Of 910 eligible child contacts, 670 (74%) started preventive therapy, 569 (85%) of whom completed therapy.

CONCLUSION

The strengthening of child TB services at peripheral health facilities in Uganda was associated with increased case finding, improved treatment outcomes and the successful implementation of contact screening and management.

摘要

背景

在基层卫生机构缺乏诊断儿童结核病(TB)的能力,且接触者筛查和管理工作有限,这导致在结核病流行地区的病例检出率较低。

目的

评估在乌干达基层卫生机构加强儿童结核病诊断、治疗和预防的试点项目的实施情况。

方法

2015 年 6 月,对基层卫生机构的卫生保健工作者进行了诊断和治疗儿童结核病的培训,并对社区卫生保健工作者进行了筛查家庭结核接触者的培训。采用前后分析以及与非干预地区的比较,评估对病例检出量和治疗结果的影响。

结果

截至 2016 年 12 月,平均每季度诊断出的儿童(年龄<15 岁)结核病患者数量从 45 例增加到 108 例。儿童结核病在所有结核病病例中的比例从 8.8%增加到 15%,完成治疗的比例从 65%增加到 82%。对 2270 名儿童结核病接触者进行筛查,发现 55 名(2.4%)患有结核病。在 910 名符合条件的儿童接触者中,有 670 名(74%)开始预防性治疗,其中 569 名(85%)完成了治疗。

结论

乌干达基层卫生机构加强儿童结核病服务与病例检出量增加、治疗结果改善以及成功实施接触者筛查和管理有关。

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本文引用的文献

2
Outcome of Children With Presumptive Tuberculosis in Mbarara, Rural Uganda.
Pediatr Infect Dis J. 2018 Feb;37(2):147-152. doi: 10.1097/INF.0000000000001727.
3
Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda.
Int J Tuberc Lung Dis. 2017 Aug 1;21(8):862-868. doi: 10.5588/ijtld.16.0889.
4
The management of infection with Mycobacterium tuberculosis in young children post-2015: an opportunity to close the policy-practice gap.
Expert Rev Respir Med. 2017 Jan;11(1):41-49. doi: 10.1080/17476348.2016.1267572. Epub 2016 Dec 10.
5
6
Uptake of Isoniazid Preventive Therapy among Under-Five Children: TB Contact Investigation as an Entry Point.
PLoS One. 2016 May 19;11(5):e0155525. doi: 10.1371/journal.pone.0155525. eCollection 2016.
7
Challenges to delivery of isoniazid preventive therapy in a cohort of children exposed to tuberculosis in Timor-Leste.
Trop Med Int Health. 2015 Jun;20(6):730-6. doi: 10.1111/tmi.12479. Epub 2015 Mar 5.
8
Tuberculosis as a cause or comorbidity of childhood pneumonia in tuberculosis-endemic areas: a systematic review.
Lancet Respir Med. 2015 Mar;3(3):235-43. doi: 10.1016/S2213-2600(15)00028-4. Epub 2015 Jan 29.
10
Importance of tuberculosis control to address child survival.
Lancet. 2014 May 3;383(9928):1605-7. doi: 10.1016/S0140-6736(14)60420-7. Epub 2014 Mar 24.

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