The Suzuki-Miyaura cross-coupling of organoboron nucleophiles with aryl halide electrophiles is one of the most widely used carbon-carbon bond-forming reactions in organic and medicinal chemistry. A key challenge associated with these transformations is that they generally require the addition of an exogenous base, the role of which is to enable transmetallation between the organoboron nucleophile and the metal catalyst. This requirement limits the substrate scope of the reaction because the added base promotes competitive decomposition of many organoboron substrates. As such, considerable research has focused on strategies for mitigating base-mediated side reactions. Previous efforts have primarily focused either on designing strategically masked organoboron reagents (to slow base-mediated decomposition) or on developing highly active palladium precatalysts (to accelerate cross-coupling relative to base-mediated decomposition pathways). An attractive alternative approach involves identifying combinations of catalyst and electrophile that enable Suzuki-Miyaura-type reactions to proceed without an exogenous base. Here we use this approach to develop a nickel-catalysed coupling of aryl boronic acids with acid fluorides, which are formed in situ from readily available carboxylic acids. This combination of catalyst and electrophile enables a mechanistic manifold in which a 'transmetallation-active' aryl nickel fluoride intermediate is generated directly in the catalytic cycle. As such, this transformation does not require an exogenous base and is applicable to a wide range of base-sensitive boronic acids and biologically active carboxylic acids.