中国大陆地区的爱泼斯坦-巴尔病毒阳性T/NK细胞淋巴增殖性疾病
Epstein-Barr Virus-Positive T/NK-Cell Lymphoproliferative Diseases in Chinese Mainland.
作者信息
Ai Junhong, Xie Zhengde
机构信息
Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
出版信息
Front Pediatr. 2018 Oct 9;6:289. doi: 10.3389/fped.2018.00289. eCollection 2018.
Abstract
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders (EBV T/NK LPD) encompass a heterogeneous group of disorders, including chronic active Epstein-Barr virus infection (CAEBV), Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH), systemic EBV T-cell lymphoma of childhood and hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) and so on, predominantly affecting children and young adults with high mortality. Patients with EBV T/NK LPD have overlapping clinical symptoms as well as histologic and immunophenotypic features. In this review, we summarized the clinical features of EBV T/NK LPD in Chinese patients from the published articles.
摘要
爱泼斯坦-巴尔病毒阳性T/NK细胞淋巴增殖性疾病（EBV T/NK LPD）包括一组异质性疾病，包括慢性活动性爱泼斯坦-巴尔病毒感染（CAEBV）、爱泼斯坦-巴尔病毒相关噬血细胞性淋巴组织细胞增生症（EBV-HLH）、儿童系统性EBV T细胞淋巴瘤和种痘样水疱病样淋巴增殖性疾病（HVLPD）等，主要影响儿童和年轻人，死亡率很高。EBV T/NK LPD患者具有重叠的临床症状以及组织学和免疫表型特征。在本综述中，我们从已发表的文章中总结了中国患者EBV T/NK LPD的临床特征。
相似文献
1
Epstein-Barr Virus-Positive T/NK-Cell Lymphoproliferative Diseases in Chinese Mainland.中国大陆地区的爱泼斯坦-巴尔病毒阳性T/NK细胞淋巴增殖性疾病
Front Pediatr. 2018 Oct 9;6:289. doi: 10.3389/fped.2018.00289. eCollection 2018.
2
Systemic Epstein-Barr Virus-Positive T/NK Lymphoproliferative Diseases With / Hypomorphic Gene Variants.伴有低表达基因变异的系统性爱泼斯坦-巴尔病毒阳性T/NK淋巴细胞增殖性疾病
Front Pediatr. 2019 May 21;7:183. doi: 10.3389/fped.2019.00183. eCollection 2019.
3
Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorders.爱泼斯坦-巴尔病毒相关的T/自然杀伤细胞淋巴增殖性疾病
J Dermatol. 2014 Jan;41(1):29-39. doi: 10.1111/1346-8138.12322.
4
Clinicopathological categorization of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications.爱泼斯坦-巴尔病毒阳性T/NK细胞淋巴增殖性疾病的临床病理分类：42例分析并着重探讨预后意义
Leuk Lymphoma. 2017 Jan;58(1):53-63. doi: 10.1080/10428194.2016.1179297. Epub 2016 May 9.
5
Spectrum of Epstein-Barr virus-associated T-cell lymphoproliferative disorder in adolescents and young adults in Taiwan.台湾青少年和青年中爱泼斯坦-巴尔病毒相关T细胞淋巴增殖性疾病的谱系
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2430-7. eCollection 2014.
6
Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach.EB 病毒相关 T/NK 细胞淋巴组织增生性疾病：最新研究进展与诊断方法。
Pathology. 2020 Jan;52(1):111-127. doi: 10.1016/j.pathol.2019.09.011. Epub 2019 Nov 22.
7
Epstein - Barr virus positive T and NK-cell lymphoproliferations: Morphological features and differential diagnosis.EB 病毒阳性 T 和 NK 细胞淋巴组织增生性疾病：形态学特征和鉴别诊断。
Semin Diagn Pathol. 2020 Jan;37(1):32-46. doi: 10.1053/j.semdp.2019.12.004. Epub 2019 Dec 17.
8
Atypical hydroa vacciniforme-like epstein-barr virus associated T/NK-cell lymphoproliferative disorder.非典型痘疮样水疱病样爱泼斯坦-巴尔病毒相关T/NK细胞淋巴增殖性疾病
Am J Dermatopathol. 2012 Dec;34(8):e119-24. doi: 10.1097/DAD.0b013e3181c036de.
9
EBV-Positive T/NK-Cell Lymphoproliferative Disease of Childhood.儿童EB病毒阳性T/NK细胞淋巴增殖性疾病
Korean J Pathol. 2013 Apr;47(2):137-47. doi: 10.4132/KoreanJPathol.2013.47.2.137. Epub 2013 Apr 24.
10
[The understanding of Epstein-Barr virus associated lymphoproliferative disorder].[对爱泼斯坦-巴尔病毒相关淋巴增殖性疾病的认识]
Zhonghua Bing Li Xue Za Zhi. 2016 Dec 8;45(12):817-821. doi: 10.3760/cma.j.issn.0529-5807.2016.12.001.
引用本文的文献
1
Giant cutaneous ulcer in Epstein-Barr virus positive T-cell/NK-cell lymphoproliferative disorder: A case report.爱泼斯坦-巴尔病毒阳性T细胞/NK细胞淋巴增殖性疾病中的巨大皮肤溃疡：一例报告
World J Clin Cases. 2025 Aug 6;13(22):104258. doi: 10.12998/wjcc.v13.i22.104258.
2
Deep insight into cytokine storm: from pathogenesis to treatment.深入洞察细胞因子风暴：从发病机制到治疗。
Signal Transduct Target Ther. 2025 Apr 16;10(1):112. doi: 10.1038/s41392-025-02178-y.
3
An analysis of sintilimab combined with ruxolitinib as compassionate therapy for 12 adults with EBV-associated hemophagocytic lymphohistiocytosis.信迪利单抗联合鲁索替尼作为12例成人EB病毒相关噬血细胞性淋巴组织细胞增生症同情用药治疗的分析
Ann Hematol. 2023 Dec;102(12):3325-3333. doi: 10.1007/s00277-023-05476-z. Epub 2023 Oct 3.
4
The roles of DNA methylation on the promotor of the Epstein-Barr virus (EBV) gene and the genome in patients with EBV-associated diseases.DNA 甲基化在 Epstein-Barr 病毒（EBV）基因启动子和基因组中对 EBV 相关疾病患者的作用。
Appl Microbiol Biotechnol. 2022 Jun;106(12):4413-4426. doi: 10.1007/s00253-022-12029-3. Epub 2022 Jun 28.
5
Multidisciplinary treatment of chronic active Epstein-Barr virus infection with multiple complications: a case report.慢性活动性EB病毒感染伴多种并发症的多学科治疗：一例报告
Transl Pediatr. 2021 Sep;10(9):2402-2406. doi: 10.21037/tp-21-154.
6
T Cell-Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis (HLH) Occurs in Non-Asians and Is Associated with a T Cell Activation State that Is Comparable to Primary HLH.T 细胞- Epstein-Barr 病毒相关噬血细胞性淋巴组织细胞增生症（HLH）可发生于非亚洲人群，与原发性 HLH 相当的 T 细胞激活状态相关。
J Clin Immunol. 2021 Oct;41(7):1582-1596. doi: 10.1007/s10875-021-01073-9. Epub 2021 Jun 26.
本文引用的文献
1
Comparative Study of the Clinical Pathology, Immunophenotype, Epstein-Barr Virus Infection Status, and Gene Rearrangements in Adult and Child Patients With Hydroa Vacciniforme-Like Lymphoproliferative Disorder.种痘样水疱病样淋巴增生性疾病成年与儿童患者的临床病理、免疫表型、爱泼斯坦-巴尔病毒感染状态及基因重排的比较研究
Am J Dermatopathol. 2019 Jan;41(1):7-15. doi: 10.1097/DAD.0000000000001229.
2
Hydroa vacciniforme-like lymphoproliferative disorder in an elderly Chinese patient and a literature review of adult cases.老年中国患者中类似于水疱疹样淋巴增生性疾病，并进行成人病例的文献回顾。
Int J Dermatol. 2018 Nov;57(11):1283-1292. doi: 10.1111/ijd.14050. Epub 2018 Jun 21.
3
Hydroa vacciniforme-like cutaneous T-cell lymphoma in a child: A case report.儿童种痘水疱病样皮肤T细胞淋巴瘤：一例报告
Medicine (Baltimore). 2018 Apr;97(15):e0319. doi: 10.1097/MD.0000000000010319.
4
The clinical characteristics and the features of immunophenotype of peripheral lymphocytes of adult onset chronic active Epstein-Barr virus disease at a Tertiary Care Hospital in Beijing.北京某三级甲等医院成人起病慢性活动性EB病毒病外周血淋巴细胞的临床特征及免疫表型特点
Medicine (Baltimore). 2018 Mar;97(9):e9854. doi: 10.1097/MD.0000000000009854.
5
Hydroa Vacciniforme-Like Cutaneous T-Cell Lymphoma in an Adult Presenting With Facial Edema and Recurrent Oral Ulceration.一名成年患者出现面部水肿和复发性口腔溃疡，诊断为痘疮样水疱病样皮肤T细胞淋巴瘤。
Am J Dermatopathol. 2018 Mar;40(3):227-229. doi: 10.1097/DAD.0000000000000845.
6
Chronic Active Epstein-Barr Virus Disease.慢性活动性EB病毒病
Front Immunol. 2017 Dec 22;8:1867. doi: 10.3389/fimmu.2017.01867. eCollection 2017.
7
Chronic active Epstein-Barr virus infection as the initial symptom in a Janus kinase 3 deficiency child: Case report and literature review.慢性活动性EB病毒感染作为一名Janus激酶3缺乏症儿童的首发症状：病例报告及文献综述
Medicine (Baltimore). 2017 Oct;96(42):e7989. doi: 10.1097/MD.0000000000007989.
8
Haploidentical hematopoietic stem cell transplantation for adult patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.单倍型相合造血干细胞移植治疗成人EB病毒相关噬血细胞性淋巴组织细胞增生症患者
Leuk Lymphoma. 2018 Jan;59(1):77-84. doi: 10.1080/10428194.2017.1330467. Epub 2017 Jun 2.
9
Hydroa Vacciniforme-Like Lymphoma in Tibetan Children: 2 Cases and a Literature Review.藏族儿童种痘水疱病样淋巴瘤：2例报告并文献复习
Am J Dermatopathol. 2018 May;40(5):358-361. doi: 10.1097/DAD.0000000000000880.
10
PEG-aspargase and DEP regimen combination therapy for refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.聚乙二醇天冬酰胺酶与DEP方案联合治疗难治性EB病毒相关噬血细胞性淋巴组织细胞增生症。
J Hematol Oncol. 2016 Sep 9;9(1):84. doi: 10.1186/s13045-016-0317-7.
Zotero 插件