Ai Junhong, Xie Zhengde
Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Front Pediatr. 2018 Oct 9;6:289. doi: 10.3389/fped.2018.00289. eCollection 2018.
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders (EBV T/NK LPD) encompass a heterogeneous group of disorders, including chronic active Epstein-Barr virus infection (CAEBV), Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH), systemic EBV T-cell lymphoma of childhood and hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) and so on, predominantly affecting children and young adults with high mortality. Patients with EBV T/NK LPD have overlapping clinical symptoms as well as histologic and immunophenotypic features. In this review, we summarized the clinical features of EBV T/NK LPD in Chinese patients from the published articles.
爱泼斯坦-巴尔病毒阳性T/NK细胞淋巴增殖性疾病（EBV T/NK LPD）包括一组异质性疾病，包括慢性活动性爱泼斯坦-巴尔病毒感染（CAEBV）、爱泼斯坦-巴尔病毒相关噬血细胞性淋巴组织细胞增生症（EBV-HLH）、儿童系统性EBV T细胞淋巴瘤和种痘样水疱病样淋巴增殖性疾病（HVLPD）等，主要影响儿童和年轻人，死亡率很高。EBV T/NK LPD患者具有重叠的临床症状以及组织学和免疫表型特征。在本综述中，我们从已发表的文章中总结了中国患者EBV T/NK LPD的临床特征。
