Cu 从淀粉样蛋白-β到金属硫蛋白-3的转移：神经递质谷氨酸和金属硫蛋白-3 Zn（ii）负载状态的作用。
Cu transfer from amyloid-β to metallothionein-3: the role of the neurotransmitter glutamate and metallothionein-3 Zn(ii)-load states.
机构信息
Institut de Chimie, UMR 7177, CNRS-Université de Strasbourg, 4 rue Blaise Pascal, 67000, Strasbourg, France.
出版信息
Chem Commun (Camb). 2018 Nov 6;54(89):12634-12637. doi: 10.1039/c8cc06221h.
PMID:30357199
Abstract
Copper transfer from Cu(ii)amyloid-β4-16 to human Zn7-metallothionein-3 can be accelerated by glutamate and by lowering the Zn-load of metallothionein-3 with EDTA. Glutamate facilitates the Cu(ii) release, and Zn4-6-metallothionein-3 react more rapidly. These mechanisms are additive, proving the intricate and interconnected network of zinc and copper trafficking between biomolecules.
摘要
谷氨酸和 EDTA 降低金属硫蛋白 3 的锌负荷均可加速 Cu（ii）淀粉样β4-16 向人 Zn7-金属硫蛋白 3 的铜转移。谷氨酸促进 Cu（ii）释放，Zn4-6-金属硫蛋白 3 反应更快。这些机制是累加的，证明了生物分子之间锌和铜转运的复杂相互关联网络。
Zotero 插件