新型环金属铂化合物对 Cu 与淀粉样β肽结合的干扰。
Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide.
机构信息
CNRS, LCC (Laboratoire de Chimie de Coordination), Toulouse, France.
出版信息
Dalton Trans. 2012 Jun 7;41(21):6404-7. doi: 10.1039/c2dt12177h. Epub 2012 Feb 3.
PMID:22301852
Abstract
Coordination of a cyclometallated Pt(II) complex (1) to an amyloid-β peptide was probed by NMR and ESI-MS. Furthermore, EPR showed that binding of 1 to the Cu(II)-amyloid-β species resulted in a reshuffling of the Cu(II) coordination sphere, which was absent or lower for the sister non cyclometallated Pt(II) complexes.
摘要
通过 NMR 和 ESI-MS 研究了金属 Pt(II) 配合物（1）与淀粉样β肽的配位协同作用。此外，EPR 表明，1 与 Cu(II)-淀粉样β物种的结合导致 Cu(II)配位球的重排，而对于姐妹非金属 Pt(II)配合物，这种重排不存在或程度较低。
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