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[根据2018年德国肺癌指南进行的病理解剖诊断]

[Pathological-anatomical diagnosis according to the German lung cancer guideline 2018].

作者信息

Junker K, Büttner R, Langer T, Ukena D

机构信息

Zentrum für Pathologie, Klinikum Bremen-Mitte, St.-Jürgen-Str. 1, 28177, Bremen, Deutschland.

Institut für Pathologie, Universitätsklinik Köln, Köln, Deutschland.

出版信息

Pathologe. 2018 Nov;39(6):589-603. doi: 10.1007/s00292-018-0531-x.

Abstract

The German S3-guideline on prevention, diagnosis, therapy and follow-up of lung cancer, published in February 2018, expands on the 2010 guideline to include a total of 19 recommendations and statements regarding the "processing of lung resection specimens (tumor resection specimens)", "processing of lymph nodes", "histo-pathological typing and immunophenotype", "extent of tumor growth in resection specimens", "resection margins" or "R-classification", "grade of malignancy (grading)", "regression grading" as well as the "examination of molecular targets". The statements regarding the analysis of molecular targets result from the diagnostic requirements of the current targeted therapy of advanced lung cancer. At the same time, a pathological-anatomical diagnosis according to the current S3-guideline fulfills all corresponding requirements in certified lung cancer centers.

摘要

2018年2月发布的德国肺癌预防、诊断、治疗及随访S3指南,在2010年指南基础上进行了扩充,共纳入了19条关于“肺切除标本(肿瘤切除标本)处理”“淋巴结处理”“组织病理学分型及免疫表型”“切除标本中肿瘤生长范围”“切缘”或“R分级”“恶性程度(分级)”“消退分级”以及“分子靶点检测”的建议和声明。关于分子靶点分析的声明源自当前晚期肺癌靶向治疗的诊断需求。同时,按照现行S3指南进行的病理解剖诊断满足了认证肺癌中心的所有相应要求。

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