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蛋白质基材料的进展:从起源到新型生物材料。

Advances in Protein-Based Materials: From Origin to Novel Biomaterials.

机构信息

Regional Research Institute for Fiber&Fashion Materials, Yeungnam University, Gyeongsan, South Korea.

School of Chemical Engineering, Yeungnam University, Gyeongsan, South Korea.

出版信息

Adv Exp Med Biol. 2018;1078:161-210. doi: 10.1007/978-981-13-0950-2_10.

Abstract

Biomaterials play a very important role in biomedicine and tissue engineering where they directly affect the cellular activities and their microenvironment . Myriad of techniques have been employed to fabricate a vast number natural, artificial and recombinant polymer s in order to harness these biomaterials in tissue regene ration , drug delivery and various other applications. Despite of tremendous efforts made in this field during last few decades, advanced and new generation biomaterials are still lacking. Protein based biomaterials have emerged as an attractive alternatives due to their intrinsic properties like cell to cell interaction , structural support and cellular communications. Several protein based biomaterials like, collagen , keratin , elastin , silk protein and more recently recombinant protein s are being utilized in a number of biomedical and biotechnological processes. These protein-based biomaterials have enormous capabilities, which can completely revolutionize the biomaterial world. In this review, we address an up-to date review on the novel, protein-based biomaterials used for biomedical field including tissue engineering, medical science, regenerative medicine as well as drug delivery. Further, we have also emphasized the novel fabrication techniques associated with protein-based materials and implication of these biomaterials in the domain of biomedical engineering .

摘要

生物材料在生物医药和组织工程中起着非常重要的作用,它们直接影响细胞的活动及其微环境。为了利用这些生物材料进行组织再生、药物输送和各种其他应用,已经采用了无数技术来制造大量的天然、人工和重组聚合物。尽管在过去几十年中,该领域做出了巨大努力,但仍缺乏先进的新一代生物材料。基于蛋白质的生物材料因其内在特性,如细胞间相互作用、结构支撑和细胞通讯,已成为一种有吸引力的替代品。几种基于蛋白质的生物材料,如胶原蛋白、角蛋白、弹性蛋白、丝蛋白,以及最近的重组蛋白,正被应用于许多生物医学和生物技术过程中。这些基于蛋白质的生物材料具有巨大的潜力,可以彻底改变生物材料领域。在这篇综述中,我们讨论了用于生物医学领域的新型蛋白质基生物材料的最新进展,包括组织工程、医学、再生医学以及药物输送。此外,我们还强调了与蛋白质基材料相关的新型制造技术,以及这些生物材料在生物医学工程领域的应用。

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