活性氧响应型天然存在的基于酚类的聚合前药。
Reactive Oxygen Species Responsive Naturally Occurring Phenolic-Based Polymeric Prodrug.
机构信息
Department of Physiology, Research Institute for Endocrine Sciences, Chonbuk National University Medical School, Jeonju, South Korea.
Molecular Imaging and Therapeutic Medicine Research Center, Cyclotron Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Chonbuk National University Medical School and Hospital, Jeonju-si, Jeollabuk-do, South Korea.
出版信息
Adv Exp Med Biol. 2018;1078:291-301. doi: 10.1007/978-981-13-0950-2_15.
Reactive Oxygen Species (ROS) play a vital role in the biological system. Exaggerated, ROS have devastating effects on the human body leading to the pathophysiological condition including the transformation of a normal cell into a cancer phenotype. Nature has blessed us with various biomolecules that we use along with our dietary supplements. Using such therapeutic small molecules covalently incorporated into biodegradable polyoxalate polymer backbone with a responsive group forms an efficient drug delivery vehicle. This chapter "Reactive oxygen species responsive naturally occurring phenolic-based polymeric prodrug" will be focusing on redox-responsive polymers incorporated with naturally occurring phenolics and clinical application.
活性氧（ROS）在生物系统中起着至关重要的作用。ROS 过度产生会对人体造成破坏性影响，导致病理生理状况，包括正常细胞向癌症表型的转化。大自然赋予了我们各种生物分子，我们可以将其与膳食补充剂一起使用。使用这种治疗性小分子，通过共价键结合到具有响应性基团的可生物降解的聚三亚甲基碳酸酯聚合物主链上，形成有效的药物传递载体。本章“活性氧响应性天然酚类聚合物前药”将重点介绍与天然酚类化合物结合的氧化还原响应性聚合物及其临床应用。
Zotero 插件