维生素 D 受体基因多态性与肠道病毒 71 引起的手足口病严重程度的关联。

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71.

机构信息

Department of Infectious Diseases, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, China.

Department of Infectious Diseases, Xi'an Children's Hospital, Xi'an, China.

出版信息

J Med Virol. 2019 Apr;91(4):598-605. doi: 10.1002/jmv.25349. Epub 2018 Nov 22.

DOI:10.1002/jmv.25349

PMID:30357860

Abstract

Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case-control study aimed to assess the association of single-nucleotide polymorphisms (SNPs) in the gene encoding the VDR with the severity of EV71-associated HFMD. We selected four VDR SNPs based on linkage disequilibrium and functional prediction, and we tested them using the SNPscan multiple SNP typing method for potential association with severity of EV71-associated HFMD. We found a significant association in the case of rs11574129 (G vs A: odds ratio (OR), 0.3439; 95% confidence intervals (CI), 0.1778-0.6653) and rs739837 (T vs G: OR, 0.5580; 95%CI, 0.3352-0.9291). Our results suggest that these two SNPs may influence the severity of EV71-associated HFMD.

摘要

严重手足口病（HFMD）有时与严重并发症相关，这些并发症可能导致大量儿童死亡。维生素 D 受体（VDR）的活性可能会影响肠道病毒 71 型（EV71）感染的结果。本病例对照研究旨在评估编码 VDR 的基因中单核苷酸多态性（SNPs）与 EV71 相关 HFMD 严重程度的关联。我们根据连锁不平衡和功能预测选择了四个 VDR SNPs，并使用 SNPscan 多 SNP 分型方法测试了它们与 EV71 相关 HFMD 严重程度的潜在关联。我们发现 rs11574129（G 对 A：比值比（OR），0.3439；95%置信区间（CI），0.1778-0.6653）和 rs739837（T 对 G：OR，0.5580；95%CI，0.3352-0.9291）存在显著关联。我们的结果表明，这两个 SNP 可能影响 EV71 相关 HFMD 的严重程度。