Department of Infectious Diseases, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, China.
Department of Infectious Diseases, Xi'an Children's Hospital, Xi'an, China.
J Med Virol. 2020 Mar;92(3):271-278. doi: 10.1002/jmv.25603. Epub 2019 Dec 2.
Coxsackievirus A16 (CA16) remains the most common causative agent of hand, foot, and mouth disease (HFMD), and is related to high incidence and critical complications. Vitamin D receptor (VDR) activity might affect the outcome of CA16 infection. Our case-control research aims to evaluate the relationship between VDR polymorphisms in the gene encoding and susceptibility to and severity of HFMD due to CA16. Three single-nucleotide polymorphisms (SNPs) of VDR gene were selected according to functional prediction and linkage disequilibrium, and were examined utilizing the SNPscan method to identify possible associations with HFMD caused by CA16. A significant relationship was found in the HFMD cases of polymorphism rs11574129 (GA vs GG: odds ratio (OR) = 0.068, 95% confidence interval (CI) = 0.007-0.693, P = .023; GA + AA vs GG: OR = 0.322, 95%CI = 0.106-0.984, P = .047), and vitamin D levels in genotype AA were significantly higher than those in genotype GG (P < .05). These results suggest that VDR rs11574129 may influence genetic susceptibility to CA16-associated HFMD.
柯萨奇病毒 A16（CA16）仍然是手足口病（HFMD）最常见的病原体，与高发病率和严重并发症有关。维生素 D 受体（VDR）的活性可能会影响 CA16 感染的结果。我们的病例对照研究旨在评估编码 VDR 的基因中的 VDR 多态性与 CA16 引起的 HFMD 的易感性和严重程度之间的关系。根据功能预测和连锁不平衡，选择了 VDR 基因的三个单核苷酸多态性（SNP），并利用 SNPscan 方法检测可能与 CA16 引起的 HFMD 相关的 SNP。在 CA16 引起的 HFMD 病例中，发现了多态性 rs11574129（GA 与 GG：比值比（OR）=0.068，95%置信区间（CI）=0.007-0.693，P=0.023；GA+AA 与 GG：OR=0.322，95%CI=0.106-0.984，P=0.047）存在显著相关性，并且基因型 AA 的维生素 D 水平明显高于基因型 GG（P<0.05）。这些结果表明，VDR rs11574129 可能影响 CA16 相关 HFMD 的遗传易感性。
