Gasperini Danila, Greenhalgh Mark D, Imad Rehan, Siddiqui Shezaib, Malik Anum, Arshad Fizza, Choudhary Muhammad Iqbal, Al-Majid Abdullah M, Cordes David B, Slawin Alexandra M Z, Nolan Steven P, Smith Andrew D
EaStCHEM, School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST, UK.
H.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Chemistry. 2019 Jan 18;25(4):1064-1075. doi: 10.1002/chem.201804653. Epub 2018 Dec 21.
During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.
在对路易斯碱异硫脲有机催化与金催化潜在结合的研究中，观察到了金 - 异硫脲配合物的形成。这些新型金配合物以高产率形成，并且发现它们对空气和湿气稳定。因此，合成并全面表征了一系列带有对映体纯异硫脲配体的中性和阳离子手性金（I）和金（III）配合物。通过计算异硫脲配体的掩埋体积百分比以及合成和分析新型铱（I） - 异硫脲羰基配合物，评估了异硫脲配体的空间和电子性质。新型金（I） - 和金（III） - 异硫脲配合物已应用于初步催化和生物学研究，并对癌细胞系和临床相关酶显示出有前景的初步催化活性和效力水平。
