Senthilselvan Ambikaipakan, Beach Jeremy
School of Public Health, University of Alberta , Edmonton , Alberta , Canada.
Department of Medicine, University of Alberta , Edmonton , Alberta , Canada.
J Asthma. 2019 Nov;56(11):1129-1137. doi: 10.1080/02770903.2018.1531997. Epub 2018 Oct 25.
: Asthma is a chronic disease affecting both children and adults, whereas chronic obstructive pulmonary disease (COPD) is a respiratory disease most commonly related to smoking and is usually seen in adults. When the airway disease shares features of both asthma and COPD, the phenotype is referred to as asthma and COPD overlap syndrome (ACOS). The objective of this cross-sectional study is to characterize ACOS in the Canadian population. : Data from the first three cycles of the Canadian Health Measures Survey (CHMS) were used in this study. The study included 9059 subjects aged 30 years and above. The CHMS included a detailed interviewer-administered questionnaire and spirometry measurements. Based on the self-report, subjects were categorized into control, ACOS, COPD only and asthma only groups. : The prevalence of ACOS, COPD and asthma groups was 1.59%, 2.21% and 6.65%, respectively. The proportion of females was significantly greater than males in the ACOS group. The proportion of wheeze was highest in the ACOS group (64.93%) whereas the prevalence of shortness of breath was the highest in the COPD group (46.25%). Heart disease, cancer, arthritis and liver disease were more prevalent in the ACOS group than in COPD, asthma and control groups. Severity of airway obstruction was the highest in the ACOS group and was followed by COPD, asthma and control groups, respectively. : Characteristics of ACOS in the Canadian population were similar to those observed in the developed countries and longitudinal studies are required to determine the incidence and risk factors of ACOS.
哮喘是一种影响儿童和成人的慢性疾病，而慢性阻塞性肺疾病（COPD）是一种最常与吸烟相关的呼吸道疾病，通常见于成年人。当气道疾病兼具哮喘和COPD的特征时，其表型被称为哮喘-慢性阻塞性肺疾病重叠综合征（ACOS）。这项横断面研究的目的是描述加拿大人群中的ACOS特征。
本研究使用了加拿大健康措施调查（CHMS）前三个周期的数据。该研究纳入了9059名30岁及以上的受试者。CHMS包括一份由访谈员详细询问的问卷和肺活量测定。根据自我报告，受试者被分为对照组、ACOS组、单纯COPD组和单纯哮喘组。
ACOS组、COPD组和哮喘组的患病率分别为1.59%、2.21%和6.65%。ACOS组中女性比例显著高于男性。哮鸣比例在ACOS组中最高（64.93%），而呼吸急促的患病率在COPD组中最高（46.25%）。ACOS组中心脏病、癌症、关节炎和肝病的患病率高于COPD组、哮喘组和对照组。气道阻塞的严重程度在ACOS组中最高，其次分别是COPD组、哮喘组和对照组。
加拿大人群中ACOS的特征与发达国家观察到的特征相似，需要进行纵向研究以确定ACOS的发病率和危险因素。
