[动脉高血压与亚甲基四氢叶酸还原酶C677T基因多态性]

[Arterial Hypertension and Methylenetetrahydrofolate Reductase C677T Gene Polymorphism].

作者信息

Pavlova O S, Ogurtsova S E, Liventseva M M, Korobko I Y, Mrochek A G

机构信息

Republican Science and Practice Center "Cardiology ".

Institute of Bioorganic Chemistry.

出版信息

Kardiologiia. 2018 Oct(10):5-11.

PMID:30359211

Abstract

OBJECTIVE

to determine the association of polymorphisms of C677T methylenetetrahydrofolate reductase (MTHFR) gene with essential arterial hypertension (EH) in the group of patients of Belarusian ethnicity.

METHODS

The clinical examination and molecular genetic study of the polymorphism C677T of MTHFR gene by polymerase chain reaction and restriction fragment length polymorphism analysis were performed in 423 people, including 315 patients with EH and 108 healthy individuals.

RESULTS

The distribution of C and T alleles of polymorphism C677T of the MTHFR gene in hypertensive patients was 67.8 and 32.2%, in normotensive individuals - 71.8 and 28.2%, respectively. In the group of hypertensive patients, the prevalence of the TT (C677T) genotype of the MTHFR gene was 10.8%, in the healthy group - 5.5%. The TT genotype of the C677T MTHFR gene was more common in hypertensive patients with obesity in comparison with hypertensive patients with body mass index < 29.9 kg/m2 (61.8 vs 38.2%, respectively; p.

摘要

目的

确定白俄罗斯族患者中677T亚甲基四氢叶酸还原酶（MTHFR）基因多态性与原发性高血压（EH）之间的关联。

方法

对423人进行了临床检查，并通过聚合酶链反应和限制性片段长度多态性分析对MTHFR基因的677T多态性进行了分子遗传学研究，其中包括315例EH患者和108名健康个体。

结果

高血压患者中MTHFR基因677T多态性的C和T等位基因分布分别为67.8%和32.2%，血压正常个体中分别为71.8%和28.2%。在高血压患者组中，MTHFR基因TT（C677T）基因型的患病率为10.8%，在健康组中为5.5%。与体重指数<29.9 kg/m²的高血压患者相比，MTHFR基因C677T的TT基因型在肥胖高血压患者中更为常见（分别为61.8%和38.2%；p.