Armario A, Montero J L, Jolin T
Ann Nutr Metab. 1987;31(2):81-7. doi: 10.1159/000177254.
Adult male Sprague-Dawley rats were subjected to food restriction so that they ate 65% of food ingested by control rats. While control rats had free access to food over the 24-hour period, food-restricted rats were provided with food daily at 10 a.m. The experimental period lasted for 34 days. On day 35, rats from both experimental groups were killed at 08.00, 11.00, 14.00, 24.00 and 02.00 h. Food restriction modified the circadian rhythms of ACTH and corticosterone. In addition, total circulating corticosterone throughout the day was higher in food-restricted than in control rats. In contrast, food restriction resulted in depressed secretion of thyroid-stimulating hormone and growth hormone. The results indicate that time of food availability entrained circadian corticosterone rhythm but not thyroid-stimulating hormone and growth hormone rhythms.
成年雄性Sprague-Dawley大鼠接受食物限制，使其进食量为对照大鼠摄入食物量的65%。对照大鼠在24小时内可自由获取食物，而食物受限的大鼠每天上午10点喂食。实验期持续34天。在第35天，两个实验组的大鼠分别于08:00、11:00、14:00、24:00和02:00处死。食物限制改变了促肾上腺皮质激素（ACTH）和皮质酮的昼夜节律。此外，食物受限大鼠全天循环皮质酮总量高于对照大鼠。相反，食物限制导致促甲状腺激素和生长激素分泌减少。结果表明，食物供应时间影响了皮质酮的昼夜节律，但不影响促甲状腺激素和生长激素的节律。
