Martí O, Gavaldà A, Jolín T, Armario A
Departament de Biologia Cel.lular i de Fisiologia, Facultat de Ciències, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Psychoneuroendocrinology. 1993;18(1):67-77. doi: 10.1016/0306-4530(93)90056-q.
Circadian variation of serum levels of adrenocorticotropin hormone (ACTH), corticosterone, growth hormone (GH), and thyroid-stimulating hormone (TSH) were studied in three groups of adult male rats exposed to chronic intermittent immobilization stress (IMO) for 2 hr daily under different schedules. IMO resulted in reduced food intake, body weight loss, and increased adrenal weight. ACTH levels were not affected but corticosterone levels were increased in all IMO rats as compared to control ones during the diurnal phase of the circadian cycle. IMO decreased serum GH and TSH levels but the circadian pattern of secretion was influenced in a complex way depending on the specific pattern of daily exposure to IMO. Differences observed between the IMO groups were not caused by differences in food intake because its circadian rhythm was very similar in all IMO groups. These results suggest that regularity of exposure to immobilization alters in a complex fashion circadian GH and TSH rhythms.
在三组成年雄性大鼠中研究了促肾上腺皮质激素（ACTH）、皮质酮、生长激素（GH）和促甲状腺激素（TSH）血清水平的昼夜变化，这三组大鼠每天在不同的时间表下接受2小时的慢性间歇性固定应激（IMO）。IMO导致食物摄入量减少、体重减轻和肾上腺重量增加。与对照组相比，在昼夜周期的昼间阶段，所有IMO大鼠的ACTH水平未受影响，但皮质酮水平升高。IMO降低了血清GH和TSH水平，但分泌的昼夜模式受到复杂的影响，这取决于每日暴露于IMO的具体模式。IMO组之间观察到的差异不是由食物摄入量的差异引起的，因为其昼夜节律在所有IMO组中非常相似。这些结果表明，暴露于固定应激的规律性以复杂的方式改变了昼夜GH和TSH节律。
