非甾体抗炎药诱导的结直肠筛查计划中的结直肠病变。
Nonsteroidal Anti-Inflammatory Drug-Induced Colopathy in a Colorectal Cancer Screening Program.
机构信息
Department of Endocrinology, Clinical Centre of Montenegro, Podgorica, Montenegro,
Department of Pathology, Clinical Centre of Montenegro, Podgorica, Montenegro.
出版信息
Med Princ Pract. 2019;28(2):193-195. doi: 10.1159/000494839. Epub 2018 Oct 25.
OBJECTIVE
To present a case of colopathy related to the use of diclofenac in a patient with a positive immunochemical faecal occult blood test (iFOBT) and to discuss the influence of nonsteroidal anti-inflammatory drugs (NSAIDs) on iFOBT specificity.
CLINICAL PRESENTATION AND INTERVENTION
A colonoscopy in a 56-year-old female presenting with a positive iFOBT revealed diaphragm-like strictures and ulcers in the right colon. While carrying out a detailed retrospective interview, she reported a chronic backache requiring long-term NSAID treatment.
CONCLUSION
No association has been established between chronic use of NSAID and a false-positive iFOBT. There is no need to stop NSAIDs before performing an iFOBT in a colorectal cancer screening program.
目的
报告一例与使用双氯芬酸相关的结肠病，该患者免疫化学粪便隐血试验（iFOBT）阳性，并讨论非甾体抗炎药（NSAIDs）对 iFOBT 特异性的影响。
临床表现及干预措施
对一名 56 岁女性进行结肠镜检查，该患者 iFOBT 阳性，结果显示右半结肠存在膈状狭窄和溃疡。在进行详细的回顾性访谈时，她报告称长期背痛需要长期使用 NSAIDs 治疗。
结论
慢性使用 NSAIDs 与 iFOBT 假阳性之间没有关联。在结直肠癌筛查计划中进行 iFOBT 之前，无需停止 NSAIDs。
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