Pocivalnik Mirjam, Danda Manfred, Urlesberger Berndt, Raith Wolfgang
Division of Neonatology, Department of Pediatrics, Medical University of Graz, 8036 Graz, Austria.
Medicines (Basel). 2018 Oct 22;5(4):113. doi: 10.3390/medicines5040113.
: Selective serotonin reuptake inhibitors are a very common choice of antidepressive drug-therapy during pregnancy. In up to 30% of cases, they have been found to cause neonatal abstinence syndrome in newborn infants. Although often both time-limiting and self-limiting, severe symptoms of neonatal abstinence syndrome (NAS) can occur. We report a term male infant suffering from a severe brief resolved unexplained event caused by his mother's sertraline intake during pregnancy. : Newborn infants exposed to selective serotonine reuptake inhibitors (SSRIs) during pregnancy should be evaluated very carefully concerning NAS and monitored for NAS symptoms for a minimum of 72⁻96 h, or until symptoms have fully recovered using standardized protocols. There is a risk of severe NAS symptoms which might occur, and this circumstance should be discussed with the parents and taken into account before administering the drug.
选择性5-羟色胺再摄取抑制剂是孕期抗抑郁药物治疗中非常常见的选择。在高达30%的病例中，已发现它们会导致新生儿出现戒断综合征。虽然新生儿戒断综合征通常具有时限性且会自行缓解，但仍可能出现严重症状。我们报告了一名足月儿男婴，因其母亲在孕期服用舍曲林而患上了一种严重的短暂性不明原因病症。孕期接触过选择性5-羟色胺再摄取抑制剂（SSRI）的新生儿应针对新生儿戒断综合征进行非常仔细的评估，并按照标准化方案对其戒断综合征症状进行至少72至96小时的监测，或直至症状完全恢复。可能会出现严重的新生儿戒断综合征症状，在给药前应与家长讨论并考虑到这种情况。
