Plush Kate, Weaver Alice, Staveley Lauren, van Wettere William
School of Animal and Veterinary Science, The University of Adelaide, Roseworthy 5371, SA, Australia.
Animals (Basel). 2018 Oct 22;8(10):185. doi: 10.3390/ani8100185.
Piglet hypoxia during farrowing is common and can lead to increased stillbirth rates, reduced piglet vitality, and an increased risk of preweaning mortality. Magnesium sulfate (MgSO₄) has successfully been used as a neuroprotectant and readily crosses the placenta in humans. Based on this human data, the aim of this study was to determine if maternal dietary supplementation with MgSO₄ prior to farrowing would reduce the impact of piglet hypoxia during the peri-natal period. Five days prior to farrowing, Large White × Landrace sows were fed either standard lactation sow diet (Cont; n = 30) or lactation diet supplemented to deliver 21 g/day MgSO₄ (Mg; n = 31). There was no effect of treatment on the percentage of stillborn piglets ( > 0.05). However, Mg piglets tended to have higher vitality scores immediately after birth ( < 0.10), were quicker to suck, and had higher day one blood glucose concentrations when compared with Cont piglets ( < 0.05). Furthermore, hypoxic piglets born to Cont sows did not gain weight from birth to 24 h, but Mg piglets did ( < 0.05), suggesting improved colostrum ingestion. In conclusion, MgSO₄ may reduce the negative impacts of birth hypoxia, improving piglet vitality, and colostrum intake during the peri-natal period.
分娩期间仔猪缺氧情况很常见，可能导致死产率增加、仔猪活力下降以及断奶前死亡率上升。硫酸镁（MgSO₄）已成功用作神经保护剂，且在人类中能轻易穿过胎盘。基于这些人类数据，本研究的目的是确定在分娩前对母猪进行日粮添加硫酸镁是否会减轻围产期仔猪缺氧的影响。在分娩前5天，大白×长白母猪被饲喂标准泌乳母猪日粮（对照组；n = 30）或添加了硫酸镁以提供21克/天硫酸镁的泌乳日粮（硫酸镁组；n = 31）。处理对死产仔猪的百分比没有影响（> 0.05）。然而，与对照组仔猪相比，硫酸镁组仔猪出生后立即的活力评分往往更高（< 0.10），吸吮更快，且出生第一天的血糖浓度更高（< 0.05）。此外，对照组母猪所生的缺氧仔猪从出生到24小时体重没有增加，但硫酸镁组仔猪增加了（< 0.05），这表明初乳摄入量有所改善。总之，硫酸镁可能会减轻出生缺氧的负面影响，提高围产期仔猪的活力和初乳摄入量。
