Agrwal Shipra, Dabas Aashima, Mantan Mukta, Yadav Sangeeta
1 Senior Resident, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
2 Assistant Professor, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
Trop Doct. 2019 Jan;49(1):52-53. doi: 10.1177/0049475518804696. Epub 2018 Oct 26.
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of unchecked activation of the immune system leading to phagocytosis of blood cells and proliferation of histiocytes in solid organs. HLH can be primary or secondary to infective, autoimmune and malignant conditions. Scrub typhus is an infective illness caused by Orientia tsutsugamushi, transmitted by mite. The illness ranges from mild fever with rash to severe multisystem illness. Scrub typhus has rarely been associated with secondary HLH. We report an infant with scrub typhus who progressed to develop HLH with central nervous system involvement with fatal outcome.
噬血细胞性淋巴组织细胞增生症（HLH）是一种免疫系统不受控制地激活导致血细胞被吞噬以及实体器官中组织细胞增殖的综合征。HLH 可以是原发性的，也可以继发于感染性、自身免疫性和恶性疾病。恙虫病是由恙虫东方体引起的一种感染性疾病，通过螨虫传播。该病症状从伴有皮疹的轻度发热到严重的多系统疾病不等。恙虫病很少与继发性 HLH 相关。我们报告了一名患恙虫病的婴儿，该婴儿进展为伴有中枢神经系统受累的 HLH，并导致致命结局。
