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用于胃肠道和肝脏疾病的益生菌:已发表文献的最新综述

Probiotics for Gastrointestinal and Liver Diseases: An Updated Review of the Published Literature.

作者信息

Dailey Francis E, Turse Erica P, Rossow Brett, Kuwajima Vanessa K, Tahan Veysel

机构信息

Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, United States.

Department of Internal Medicine, Division of Gastroenterology & Hepatology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States.

出版信息

Endocr Metab Immune Disord Drug Targets. 2019;19(5):549-570. doi: 10.2174/1871530318666181022163944.

Abstract

BACKGROUND

Probiotics can be viewed as biological agents that modify the intestinal microbiota and certain cytokine profiles, which can lead to an improvement in certain gastrointestinal diseases, including diarrhea, inflammatory bowel disease, and liver disease.

DISCUSSION

Consumption of probiotics in their various forms, including yogurt, functional foods, and dietary supplements, is frequently encountered worldwide. Often, however, the correct prescription of these agents is dampened due to a lack of knowledge of the scientific evidence and the different presentations and microbial compositions of the currently available probiotic options. Here, we provide an up-to-date review of the evidence of probiotics in the prevention and treatment of various gastrointestinal diseases.

OBJECTIVE

Consumption of probiotics in their various forms, including yogurt, functional foods, and dietary supplements, is frequently encountered worldwide. Often, however, the correct prescription of these agents is dampened due to a lack of knowledge of the scientific evidence and the different presentations and microbial compositions of the currently available probiotic options.

METHODS/RESULTS: Here, we provide an up-to-date review of the evidence of probiotics in the prevention and treatment of various gastrointestinal diseases.

CONCLUSION

While not efficacious in every disease process studied, probiotics have demonstrated some benefit in several specific gastrointestinal and liver diseases.

摘要

背景

益生菌可被视为能够改变肠道微生物群和某些细胞因子谱的生物制剂,这可使包括腹泻、炎症性肠病和肝病在内的某些胃肠道疾病得到改善。

讨论

在全球范围内,经常会遇到以各种形式食用益生菌的情况,包括酸奶、功能性食品和膳食补充剂。然而,由于缺乏科学证据方面的知识,以及对目前可用的益生菌产品的不同形式和微生物组成了解不足,这些制剂的正确使用往往受到影响。在此,我们提供了一份关于益生菌在预防和治疗各种胃肠道疾病方面证据的最新综述。

目的

在全球范围内,经常会遇到以各种形式食用益生菌的情况,包括酸奶、功能性食品和膳食补充剂。然而,由于缺乏科学证据方面的知识,以及对目前可用的益生菌产品的不同形式和微生物组成了解不足,这些制剂的正确使用往往受到影响。

方法/结果:在此,我们提供了一份关于益生菌在预防和治疗各种胃肠道疾病方面证据的最新综述。

结论

虽然益生菌并非对所研究的每个疾病过程都有效,但已在几种特定的胃肠道和肝脏疾病中显示出一定益处。

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