Neusel C, Class D, Eckert A W, Firsching R, Göbel P, Götz D, Haase R, Jorch G, Köhn A, Kropf S, Patzer L, Schanze I, Zahl C, Rissmann A
Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty Otto-von-Guericke University Magdeburg, Leipziger Str. 44, Haus 39, 39120 Magdeburg, Germany.
Universitaetsklinik fuer Neurochirurgie, Leipziger Str. 44, 39120 Magdeburg, Germany.
Br J Oral Maxillofac Surg. 2018 Nov;56(9):881-886. doi: 10.1016/j.bjoms.2018.10.003. Epub 2018 Oct 22.
We know of no current published data on the prevalence of craniosynostosis in Germany, so our objective in this study was to contribute to the limited knowledge of its epidemiology by assessing time trends, the frequency of prenatal diagnosis, and the timing of diagnosis and treatment. Data were collected in Saxony-Anhalt during the period 2000-17, and we designed a retrospective multicentre cohort study. The prevalence was 4.8 cases of craniosynostosis/10 000 births, and did not increase during that time. We compared the data of 91 patients with those of 273 controls. There were 75 boys and 16 girls (ratio 4.7:1). Fifty-one children had isolated craniosynostosis, consisting of 46 with a single-suture, and five with a multisuture, synostosis. Twenty-nine were associated with other congenital malformations, and 11 were syndromic. Three cases had been diagnosed prenatally, and 34 had skull deformities diagnosed immediately after birth at a mean (SD) age of 3.4 (4.7) months. The mean (SD) age at the time of first admission to hospital in one of the three surgical centres of Saxony-Anhalt was 5.9 (5.5) months, and 65 patients were operated on at a mean age of 9.1 (6.3) months. In contrast to published reports we found a prevalence of 4.8 cases of craniosynostosis/10 000 births that did not increase during the period 2000-16. Although we found a low prenatal detection rate, the diagnosis and treatment in this cohort study seemed timely.
我们尚未找到有关德国颅缝早闭症患病率的最新公开数据，因此本研究的目的是通过评估时间趋势、产前诊断频率以及诊断和治疗时间，来补充其流行病学方面有限的知识。2000年至2017年期间在萨克森-安哈尔特州收集了数据，我们设计了一项回顾性多中心队列研究。颅缝早闭症的患病率为每10000例出生中有4.8例，在此期间并未增加。我们将91例患者的数据与273例对照的数据进行了比较。其中有75名男孩和16名女孩（比例为4.7:1）。51名儿童患有孤立性颅缝早闭症，其中46例为单缝早闭，5例为多缝早闭。29例与其他先天性畸形有关，11例为综合征性。3例在产前被诊断出，34例在出生后立即被诊断出颅骨畸形，平均（标准差）年龄为3.4（4.7）个月。在萨克森-安哈尔特州的三个外科中心之一，首次入院时的平均（标准差）年龄为5.9（5.5）个月，65例患者在平均年龄9.1（6.3）个月时接受了手术。与已发表的报告不同，我们发现每10000例出生中颅缝早闭症的患病率为4.8例，在2000年至2016年期间并未增加。尽管我们发现产前检测率较低，但在这项队列研究中，诊断和治疗似乎是及时的。
