极早早产儿特发性中枢性尿崩症：一例报告

Idiopathic central diabetes insipidus in an extreme premature infant: A case report.

作者信息

Biset A, Claris O

机构信息

Department of neonatology, Hôpital Femme-Mère-Enfant, hospices Civils de Lyon, 59, boulevard Pinel, 69677 Lyon, France.

Department of neonatology, Hôpital Femme-Mère-Enfant, hospices Civils de Lyon, 59, boulevard Pinel, 69677 Lyon, France; EA4128, université Claude Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69100 Villeurbanne, France.

出版信息

Arch Pediatr. 2018 Nov;25(8):480-484. doi: 10.1016/j.arcped.2018.09.007. Epub 2018 Oct 22.

DOI:10.1016/j.arcped.2018.09.007

PMID:30361085

Abstract

CONTEXT

Central diabetes insipidus (CDI) is a rare disease during the neonatal period, making it diagnosis difficult and delaying medical treatment.

CASE REPORT

We report here a case of a premature infant born at 26 weeks gestation who, during his 1st month of life, presented persistent hypernatremia with polyuria despite increased fluid supply and low sodium intake. CDI diagnosis was suspected and then confirmed by the therapeutic test with vasopressin analog, in its oral form. Electrolyte disorders were normalized after treatment, which allowed normal weight and height growth with standard fluid supply. Biological and radiological tests were all normal; this CDI was considered idiopathic.

CONCLUSION

Persistent hypernatremia with excessive diuresis should alert to CDI diagnosis.

摘要

背景

中枢性尿崩症（CDI）在新生儿期是一种罕见疾病，这使得其诊断困难并延误治疗。

病例报告

我们在此报告一例孕26周出生的早产儿，在其出生后第1个月，尽管补液量增加且钠摄入量低，但仍出现持续性高钠血症伴多尿。怀疑为CDI，随后通过口服血管加压素类似物的治疗试验得以确诊。治疗后电解质紊乱恢复正常，在标准补液量情况下实现了正常的体重和身高增长。生物学和放射学检查均正常；该CDI被认为是特发性的。