Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, Tianjin University, Tianjin, 300072, China.
Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, 300070, China.
Ann Biomed Eng. 2019 Feb;47(2):563-575. doi: 10.1007/s10439-018-02156-2. Epub 2018 Oct 22.
Optical biopsy methods, such as probe-based endomicroscopy, can be used for the identification of early mucosal dysplasia in various gastrointestinal conditions and have potential applications in the screening of early-stage gastric cancer in vivo. However, it is difficult to scan a large area of the gastric mucosa for mosaicing during standard endoscopy. This paper proposes a novel 'snap-on' robotic scanning device that can integrate distally with a commercial endoscope. A customized low-cost endomicroscopy system is used for obtaining micro imaging. The developed device could scan a large area of gastric tissue during standard endoscopy. The device achieves positioning accuracy that is less than 0.23 mm. Experimental results showed that the device could achieve large area mosaicing (15.8-18.6 mm) and demonstrated the potential clinical value of the device for real-time gastric tissue identification and margin assessment. This approach presents an important alternative to current histology techniques for gastrointestinal tract diagnosis.
光学活检方法，如基于探头的内窥检查，可以用于识别各种胃肠道疾病中的早期黏膜发育不良，并且在体内筛查早期胃癌方面具有潜在的应用。然而，在标准内窥镜检查期间，很难对胃黏膜的大面积进行拼接扫描。本文提出了一种新颖的“即插即用”机器人扫描装置，可以与商业内窥镜远端集成。定制的低成本内窥检查系统用于获取微观成像。所开发的装置可以在标准内窥镜检查期间扫描大面积的胃组织。该装置实现了小于 0.23mm 的定位精度。实验结果表明，该装置可以实现大面积拼接（15.8-18.6mm），并展示了该装置在实时胃组织识别和边界评估方面的潜在临床价值。这种方法为胃肠道诊断提供了一种重要的替代当前组织学技术的方法。
