[G蛋白偶联受体的线粒体信号传导]
[Mitochondrial signaling of G protein-coupled receptors].
作者信息
Lahuna Olivier, Jockers Ralf
机构信息
Inserm, U1016, Institut Cochin, 22 rue Méchain, 75014 Paris, France - CNRS UMR 8104, Paris, France - Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
出版信息
Biol Aujourdhui. 2018;212(1-2):21-26. doi: 10.1051/jbio/2018024. Epub 2018 Oct 26.
G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with 800 members in humans that are expressed at the cell surface responding to a large panel of extracellular stimuli. Recent advances indicate that GPCRs are also expressed in intracellular compartments where they fulfil important functions. Here, we will report on the mitochondrial localization and function of GPCRs.
G蛋白偶联受体（GPCRs）是最大的整合膜受体家族，在人类中有800个成员，它们表达于细胞表面，对大量细胞外刺激作出反应。最近的研究进展表明，GPCRs也表达于细胞内区室，在那里发挥重要功能。在此，我们将报道GPCRs的线粒体定位和功能。
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