Yucel Cem, Budak Salih
Department of Urology, Tepecik Training and Research Hospital, Izmir.
Arch Ital Urol Androl. 2018 Sep 30;90(3):181-183. doi: 10.4081/aiua.2018.3.181.
We investigated the relationship between large prostate calculi and prostate cancer (PCa) risk.
The medical records of 340 patients who received a prostate biopsy at our institution between January 2015 and August 2016 were reviewed retrospectively. Of the patients, 82 had large prostatic calculi visualised by transrectal ultrasonography and 88 did not or had scarce prostatic calculi. We divided these patients into two groups: patients with large prostatic calculi (group 1) and patients without prostatic calculi (group 2). These groups were compared according to age, total prostate specific antigen (PSA) level, prostate volume, and final pathological diagnosis.
The mean age of all patients was 61.4 ± 6.2 years, the mean total PSA was 12.3 ± 17.4 ng/mL, the mean prostate volume was 41.7 ± 17.6 mL, and the overall cancer detection rate was 31.5%. The cancer detection rates were 41.3% and 22.6% in groups 1 and 2, respectively (p = 0.018). No significant differences in mean age, mean total PSA, or mean prostate volume were observed between the groups.
In the present study, large prostatic calculi were associated with PCa. However, more study is needed to examine the relationship between large prostatic calculi and PCa in more detail. The effects of particularly large prostate calculi in the development of PCa will be a necessary focus of future research.
我们研究了大前列腺结石与前列腺癌（PCa）风险之间的关系。
回顾性分析了2015年1月至2016年8月在我院接受前列腺活检的340例患者的病历。其中，经直肠超声检查发现82例有大前列腺结石，88例无或仅有少量前列腺结石。我们将这些患者分为两组：大前列腺结石患者（第1组）和无前列腺结石患者（第2组）。根据年龄、总前列腺特异性抗原（PSA）水平、前列腺体积和最终病理诊断对两组进行比较。
所有患者的平均年龄为61.4±6.2岁，平均总PSA为12.3±17.4 ng/mL，平均前列腺体积为41.7±17.6 mL，总体癌症检出率为31.5%。第1组和第2组的癌症检出率分别为41.3%和22.6%（p = 0.018）。两组之间在平均年龄、平均总PSA或平均前列腺体积方面未观察到显著差异。
在本研究中，大前列腺结石与PCa相关。然而，需要更多的研究来更详细地研究大前列腺结石与PCa之间的关系。特别大的前列腺结石在PCa发生发展中的作用将是未来研究的一个必要重点。
