Vol'skiĭ N N, Kozlov V A, Lozovoĭ V P
Biull Eksp Biol Med. 1987 Jun;103(6):694-6.
Superoxide radical production by mouse phagocytic spleen cells was shown to be essentially increased 2 hours following intraperitoneal injection of hydrocortisone acetate at a dose of 50 mg/kg body weight. The addition of hydrocortisone to the suspension of mouse spleen cells has resulted in linear dependence of hormone concentration in the incubation medium on the maximum rate of superoxide radical production. The mechanism of hydrocortisone stimulating effect on the activity of plasma membrane-located NAD(P)H-oxidase of phagocytic cells is being discussed.
腹腔注射50mg/kg体重的醋酸氢化可的松2小时后，小鼠吞噬性脾细胞的超氧自由基生成显著增加。向小鼠脾细胞悬液中添加氢化可的松后，孵育培养基中激素浓度与超氧自由基生成的最大速率呈线性相关。目前正在探讨氢化可的松对吞噬细胞膜定位的NAD(P)H氧化酶活性的刺激机制。
