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脑钠钾ATP酶活性可能受一种特定血清素受体的调节。

Brain Na+,K+-ATPase activity possibly regulated by a specific serotonin receptor.

作者信息

Hernández J

出版信息

Brain Res. 1987 Apr 7;408(1-2):399-402. doi: 10.1016/0006-8993(87)90414-8.

DOI:10.1016/0006-8993(87)90414-8
PMID:3036307
Abstract

Na+,K+-ATPase activity in 6 regions of adult brain was measured after incubation with varying concentrations of serotonin. A concentration-dependent increase in enzyme activity was observed in 4 regions, with cerebral cortex and cerebellum showing the largest response. These results together with previous ones suggest that serotonin modulates brain Na+,K+-ATPase activity through a specific receptor located in target neurons or glial cells.

摘要

在与不同浓度的血清素孵育后，测量了成年大脑6个区域的钠钾ATP酶活性。在4个区域观察到酶活性呈浓度依赖性增加，其中大脑皮层和小脑的反应最为明显。这些结果与之前的结果共同表明，血清素通过位于靶神经元或神经胶质细胞中的特定受体调节大脑钠钾ATP酶活性。

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