Henke H, Sigrist S, Lang W, Schneider J, Fischer J A
Brain Res. 1987 May 5;410(2):404-8. doi: 10.1016/0006-8993(87)90348-9.
Specific and saturable binding sites of the synthetic human calcitonin gene-related peptide-I (CGRP-I) and -II (CGRP-II) have been identified in membrane homogenates of the human central nervous system, heart and spleen. Half maximal inhibition of the binding of 125I-CGRP-II was achieved with 0.25 nM and 1.7 nM of non-radioactive CGRP-I or -II, and with 260 and 850 nM salmon calcitonin in the spinal cord and cerebellum, respectively, but 1 microM human calcitonin was not recognized. Autoradiographs of diencephalic sections revealed different distribution of 125I-CGRP-I and -II binding sites.
