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胃扩张扭转犬大隐静脉血与头静脉血乳酸浓度的比较:45例

Comparison of saphenous and cephalic blood lactate concentrations in dogs with gastric dilatation and volvulus: 45 cases.

作者信息

Oron Liron D, Klainbart Sigal, Bruchim Yaron, McMurray Jantina, Boysen Søren, Saar Matan, Kelmer Efrat

机构信息

Koret School of Veterinary Medicine Department of Emergency and Critical Care, Hebrew University of Jerusalem, Jerusalem, Israel 76100 (Oron, Klainbart, Bruchim, Kelmer, Saar); Faculty of Veterinary Medicine, Veterinary Clinical and Diagnostic Sciences, University of Calgary, Calgary, Alberta T2N 1N4 (McMurray, Boysen).

出版信息

Can J Vet Res. 2018 Oct;82(4):271-277.

Abstract

Gastric dilatation and volvulus (GDV) is a life-threatening condition, suspected to result in differential tissue perfusion in different regions of the body. Lactate is a biomarker of hypoperfusion that correlates with treatment outcomes in dogs with GDV. This prospective observational study aimed to compare lactate between saphenous and cephalic venous samples in 45 client-owned dogs with GDV, to evaluate their association with treatment outcomes (survival, surgical complications, and duration of hospitalization) and to assess the correlation between lactate and other biochemical parameters. Both saphenous and cephalic lactate concentrations were significantly higher in non-survivors ( = 0.01). No statistical difference was found between lactate concentrations in saphenous cephalic venous samples ( = 0.480). For each dog, the difference in lactate between saphenous and cephalic veins was calculated (Δlactate = saphenous - cephalic); it was not associated with survival ( = 0.198), surgical complications ( = 0.346), or duration of hospitalization ( = 0.803). Higher lactate and lower glucose (saphenous vein) were associated with lower PCV and higher creatinine, on presentation. The results of this study failed to show an association between Δlactate concentrations and treatment outcomes in dogs with GDV; however, in agreement with previous studies, lower lactate was associated with a decreased mortality rate.

摘要

胃扩张扭转(GDV)是一种危及生命的病症,据推测会导致身体不同部位的组织灌注差异。乳酸是低灌注的生物标志物,与患有GDV的犬只的治疗结果相关。这项前瞻性观察性研究旨在比较45只客户拥有的患有GDV的犬只的隐静脉和头静脉样本中的乳酸水平,评估它们与治疗结果(存活、手术并发症和住院时间)的关联,并评估乳酸与其他生化参数之间的相关性。非存活犬只的隐静脉和头静脉乳酸浓度均显著更高(P = 0.01)。隐静脉和头静脉样本中的乳酸浓度之间未发现统计学差异(P = 0.480)。对于每只犬只,计算隐静脉和头静脉之间的乳酸差异(Δ乳酸=隐静脉 - 头静脉);它与存活(P = 0.198)、手术并发症(P = 0.346)或住院时间(P = 0.803)均无关联。就诊时,较高的乳酸和较低的葡萄糖(隐静脉)与较低的红细胞压积和较高的肌酐相关。本研究结果未能显示患有GDV的犬只中Δ乳酸浓度与治疗结果之间存在关联;然而,与先前的研究一致,较低的乳酸与死亡率降低相关。

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