在中危前列腺癌患者预后分层中Gleason 4级所占的比例。
Percent Gleason pattern 4 in stratifying the prognosis of patients with intermediate-risk prostate cancer.
作者信息
Sharma Meenal, Miyamoto Hiroshi
机构信息
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Department of Urology, University of Rochester Medical Center, Rochester, NY, USA.
出版信息
Transl Androl Urol. 2018 Sep;7(Suppl 4):S484-S489. doi: 10.21037/tau.2018.03.20.
Abstract
The Gleason score remains the most reliable prognosticator in men with prostate cancer. One of the recent important modifications in the Gleason grading system recommended from the International Society of Urological Pathology consensus conference is recording the percentage of Gleason pattern 4 in the pathology reports of prostate needle biopsy and radical prostatectomy cases with Gleason score 7 prostatic adenocarcinoma. Limited data have indeed suggested that the percent Gleason pattern 4 contributes to stratifying the prognosis of patients who undergo radical prostatectomy. An additional obvious benefit of reporting percent pattern 4 includes providing critical information for treatment decisions. This review summarizes and discusses available studies assessing the utility of the percentage of Gleason pattern 4 in the management of prostate cancer patients.
摘要
Gleason评分仍然是前列腺癌男性患者最可靠的预后指标。国际泌尿病理学会共识会议推荐的Gleason分级系统最近的一项重要修订是，在Gleason评分为7分的前列腺腺癌的前列腺穿刺活检和根治性前列腺切除术病例的病理报告中记录Gleason 4级模式的百分比。确实有有限的数据表明，Gleason 4级模式的百分比有助于对接受根治性前列腺切除术的患者的预后进行分层。报告4级模式百分比的另一个明显好处是为治疗决策提供关键信息。本综述总结并讨论了评估Gleason 4级模式百分比在前列腺癌患者管理中的效用的现有研究。
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