Czarniecki Marcin, Pesapane Filippo, Wood Bradford J, Choyke Peter L, Turkbey Baris
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Postgraduate School in Radiodiagnostics, Università degli Studi di Milano, Milan, Italy.
Transl Androl Urol. 2018 Sep;7(Suppl 4):S453-S461. doi: 10.21037/tau.2018.05.15.
Ultrasmall superparamagnetic particles of iron oxide (USPIOs) imaged with magnetic resonance imaging (MRI) have been proposed as an experimental method for visualizing lymph node (LN) metastases. The method does not require ionizing radiation, yet can detect small nodes that are involved with metastases. USPIOs are naturally taken up by macrophages that deposit in the normal LN creating a low signal region in normal areas; areas within the node that do not show this loss of signal are likely involved by tumor although there can be other causes (fibrosis or inflammation). However, the lack of approved USPIOs that are clinically available hinders adoption and larger studies. The proposed indications for USPIO MRI, including specific compounds and imaging methods are discussed.
用磁共振成像（MRI）成像的超小超顺磁性氧化铁颗粒（USPIOs）已被提议作为一种可视化淋巴结（LN）转移的实验方法。该方法不需要电离辐射，但可以检测到有转移的小淋巴结。USPIOs会被巨噬细胞自然摄取，巨噬细胞沉积在正常淋巴结中，在正常区域形成低信号区；淋巴结内未出现这种信号缺失的区域可能被肿瘤累及，不过也可能有其他原因（纤维化或炎症）。然而，缺乏临床可用的已获批USPIOs阻碍了其应用和更大规模的研究。本文讨论了USPIO MRI的拟用适应症，包括特定化合物和成像方法。
