Soodana-Prakash Nachiketh, Stoyanova Radka, Bhat Abhishek, Velasquez Maria C, Kineish Omer E, Pollack Alan, Parekh Dipen J, Punnen Sanoj
Department of Urology, University of Miami, Miami, FL, USA.
Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Transl Androl Urol. 2018 Sep;7(Suppl 4):S443-S452. doi: 10.21037/tau.2018.07.04.
Radiogenomics is a field that amalgamates data from genomics and imaging techniques in order to derive clinically meaningful trends. In this article, we discuss the importance of prostate cancer risk classification and how data derived from genomic testing and multi-parametric magnetic resonance imaging (mpMRI) can be integrated into clinical decision-making processes with a focus on active surveillance (AS). Finally, we describe an ongoing prospective trial (Miami MAST trial) which incorporates imaging (mpMRI) and radiomics data in patients who are on AS for prostate cancer.
放射基因组学是一个融合基因组学数据和成像技术以得出具有临床意义趋势的领域。在本文中,我们讨论前列腺癌风险分类的重要性,以及如何将基因组检测和多参数磁共振成像(mpMRI)得出的数据整合到临床决策过程中,重点是主动监测(AS)。最后,我们描述了一项正在进行的前瞻性试验(迈阿密MAST试验),该试验纳入了接受前列腺癌主动监测患者的成像(mpMRI)和放射组学数据。