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孕期安全注射A型肉毒杆菌毒素：两例报告

Safe Administration of Botulinum Toxin Type A Injections During Pregnancy: A Report of Two Cases.

作者信息

Krug Henriette, Krause Patricia, Kupsch Andreas, Kühn Andrea A

机构信息

Department of Neurology Charité-University Medicine Berlin Berlin Germany.

Department of Neurology and Functional Neurosurgery Otto von Guericke University Magdeburg Germany.

出版信息

Mov Disord Clin Pract. 2015 May 6;2(2):187-189. doi: 10.1002/mdc3.12135. eCollection 2015 Jun.

DOI:10.1002/mdc3.12135
PMID:30363903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6183313/
Abstract

Local injections of botulinum toxin type A (BoNT/A) are safe and efficacious to treat focal and segmental dystonia. However, there are no adequate studies in humans regarding the safety of BoNT/A during pregnancy. Despite the fact that 25 case reports have been published on patients who received BoNT/A injections during a total of 31 pregnancies, in only 3 patients were the injections continued beyond the first trimester. We report on 2 females with cervical and segmental dystonia who received BoNT/A injections during pregnancy beyond the first trimester and gave birth to 2 healthy children.

摘要

局部注射A型肉毒杆菌毒素（BoNT/A）治疗局限性和节段性肌张力障碍安全有效。然而，关于孕期使用BoNT/A的安全性，尚无充分的人体研究。尽管已有25例关于在31次妊娠期间接受BoNT/A注射患者的病例报告发表，但只有3例患者在孕早期后仍继续注射。我们报告2例患有颈部和节段性肌张力障碍的女性，她们在孕早期后接受了BoNT/A注射，并生下了2名健康婴儿。

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