de Oliveira Monteiro Erica
Dermatology Cosmetic Center Federal University of São Paulo, Brazil.
Skinmed. 2006 Nov-Dec;5(6):308. doi: 10.1111/j.1540-9740.2006.05584.x.
The overall use of botulinum toxin type A in cosmetic procedures continues to rise, and the incidental exposures of pregnant women to the drug can occur. The author describes 2 patients who received botulinum toxin type A injections during pregnancy. The first patient was a 34-year-old woman who received 54 units of botulinum toxin type A to treat periorbital lines (crow's feet) unaware that she was 6 weeks pregnant. She had a healthy term baby delivered by cesarean section; Apgar scores were 9/10. The second patient was a 37-year-old woman who received 65 units of botulinum toxin type A to treat facial dynamic lines (forehead, glabelar, and periorbital), unaware that she was 5 weeks pregnant. She had a healthy term baby delivered by cesarean section; Apgar scores were 9/10. The 2 patients were injected only once in the first trimester. Both cases did not have any complications or detectable adverse effects on the fetuses.
A型肉毒杆菌毒素在美容手术中的总体使用量持续上升，孕妇可能会意外接触到这种药物。作者描述了2例在孕期接受A型肉毒杆菌毒素注射的患者。首例患者为一名34岁女性，在不知自己已怀孕6周的情况下，接受了54单位A型肉毒杆菌毒素以治疗眶周纹（鱼尾纹）。她通过剖宫产分娩了一名健康的足月儿；阿氏评分分别为9分和10分。第二例患者是一名37岁女性，在不知自己已怀孕5周的情况下，接受了65单位A型肉毒杆菌毒素以治疗面部动态纹（额头、眉间和眶周）。她通过剖宫产分娩了一名健康的足月儿；阿氏评分分别为9分和10分。这2例患者均仅在孕早期注射了一次。两例均未出现任何并发症，也未发现对胎儿有可检测到的不良影响。
