人体骨骼中年龄与重金属元素浓度之间的关系研究。
Study on the relationship between age and the concentrations of heavy metal elements in human bone.
作者信息
Chang Liang, Shen Sheng, Zhang Zhe, Song Xiaoxiao, Jiang Qing
机构信息
Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing 210000, China.
Joint Research Center for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China.
出版信息
Ann Transl Med. 2018 Aug;6(16):320. doi: 10.21037/atm.2018.08.09.
BACKGROUND
Excessive amounts of heavy metals such as cadmium, chromium, cobalt, lead, thallium, and manganese are extremely harmful to the human body. These elements can accumulate in bone and impact bone metabolism. In this study, we investigated the relationship between age and the concentrations of these elements in human bone and blood.
METHODS
Bone and blood samples were obtained from both older and younger patients. The concentrations of the elements under investigation were measured by inductively coupled plasma mass spectrometry (ICP-MS), and the specific concentrations in the bone and blood were then calculated.
RESULTS
The results showed that with increasing age, the concentrations of chromium, cobalt, and thallium in bone decreased significantly, while the concentration of cadmium in bone markedly increased. However, there was no clear correlation between age and the concentrations of these heavy metals in blood. Notably, there was a close correlation between the concentration of cobalt in bone and the presence of osteopenia.
CONCLUSIONS
Senescence of the human body is accompanied by the shifting of cobalt, chromium, and thallium from the bone to the outer- bone. However, the concentration of cadmium in bone increases with age. These changes are very likely to be related to the equilibrium of bone metabolism in senescent individuals. In addition, only cobalt was shown to be significantly related to osteopenia.
背景
过量的重金属，如镉、铬、钴、铅、铊和锰，对人体极其有害。这些元素可在骨骼中蓄积并影响骨代谢。在本研究中，我们调查了年龄与人体骨骼和血液中这些元素浓度之间的关系。
方法
从老年和年轻患者中获取骨骼和血液样本。通过电感耦合等离子体质谱法（ICP-MS）测量所研究元素的浓度，然后计算骨骼和血液中的具体浓度。
结果
结果显示，随着年龄的增长，骨骼中铬、钴和铊的浓度显著降低，而骨骼中镉的浓度显著增加。然而，年龄与血液中这些重金属的浓度之间没有明显的相关性。值得注意的是，骨骼中钴的浓度与骨质减少的存在密切相关。
结论
人体衰老伴随着钴、铬和铊从骨骼向骨外转移。然而，骨骼中镉的浓度随年龄增长而增加。这些变化很可能与衰老个体骨代谢的平衡有关。此外，仅显示钴与骨质减少显著相关。
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