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Human Regular 500 units/mL Insulin Therapy: A Review of Clinical Evidence and New Delivery Options.

作者信息

Sze David, Goldman Jennifer

机构信息

Becton Dickinson, Andover, MA.

MCPHS University, Boston, MA.

出版信息

Clin Diabetes. 2018 Oct;36(4):319-324. doi: 10.2337/cd18-0004.

DOI:10.2337/cd18-0004
PMID:30364062
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6187959/
Abstract
摘要

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Pharmacokinetics and Pharmacodynamics of Human Regular U-500 Insulin Administered via Continuous Subcutaneous Insulin Infusion Versus Subcutaneous Injection in Adults With Type 2 Diabetes and High-Dose Insulin Requirements.U-500 人胰岛素在成人 2 型糖尿病和高剂量胰岛素需求患者中的药代动力学和药效学:连续皮下胰岛素输注与皮下注射比较。
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本文引用的文献

1
The impact of extended release exenatide as adjuvant therapy on hemoglobin A1C, weight, and total daily dose of insulin in patients with type 2 diabetes mellitus using U-500 insulin.使用 U-500 胰岛素的 2 型糖尿病患者中,长效艾塞那肽作为辅助治疗对糖化血红蛋白、体重和胰岛素日总剂量的影响。
Diabetes Res Clin Pract. 2017 Dec;134:38-43. doi: 10.1016/j.diabres.2017.09.008. Epub 2017 Sep 23.
2
Clinical Experience with U-500 Regular Insulin by Multiple Daily Injections and Continuous Subcutaneous Insulin Infusion.多次皮下注射和持续皮下胰岛素输注使用U-500常规胰岛素的临床经验
Diabetes Technol Ther. 2017 Apr;19(4):220-225. doi: 10.1089/dia.2016.0411. Epub 2017 Mar 1.
3
Patient-reported outcomes in transition from high-dose U-100 insulin to human regular U-500 insulin in severely insulin-resistant patients with type 2 diabetes: analysis of a randomized clinical trial.2型糖尿病严重胰岛素抵抗患者从高剂量U-100胰岛素转换为普通U-500人胰岛素时的患者报告结局:一项随机临床试验的分析
Health Qual Life Outcomes. 2016 Sep 30;14(1):139. doi: 10.1186/s12955-016-0541-4.
4
New Insulin Delivery Recommendations.新胰岛素输送推荐意见。
Mayo Clin Proc. 2016 Sep;91(9):1231-55. doi: 10.1016/j.mayocp.2016.06.010.
5
Insulin Injection Into Lipohypertrophic Tissue: Blunted and More Variable Insulin Absorption and Action and Impaired Postprandial Glucose Control.胰岛素注射至脂肪肥厚组织:胰岛素吸收和作用减弱且变异性更大,以及餐后血糖控制受损。
Diabetes Care. 2016 Sep;39(9):1486-92. doi: 10.2337/dc16-0610. Epub 2016 Jul 13.
6
Pen Device for U-500 Insulin; Tamper-Resistant Seals; Dispelling Myths About ISMP.U-500胰岛素笔式装置;防篡改密封;消除关于ISMP的误解。
Hosp Pharm. 2016 Apr;51(4):279-83. doi: 10.1310/hpj5104-279.
7
Management of U-500 insulin users during inpatient admissions within a Veterans Affairs Medical Center.退伍军人事务医疗中心住院期间U-500胰岛素使用者的管理
Diabetes Res Clin Pract. 2016 Apr;114:32-6. doi: 10.1016/j.diabres.2016.02.004. Epub 2016 Feb 16.
8
Sustained efficacy of insulin pump therapy compared with multiple daily injections in type 2 diabetes: 12-month data from the OpT2mise randomized trial.胰岛素泵治疗与多次皮下注射治疗2型糖尿病的持续疗效对比:来自OpT2mise随机试验的12个月数据
Diabetes Obes Metab. 2016 May;18(5):500-7. doi: 10.1111/dom.12642. Epub 2016 Mar 22.
9
EFFECT OF TOTAL DAILY DOSE ON EFFICACY, DOSING, AND SAFETY OF 2 DOSE TITRATION REGIMENS OF HUMAN REGULAR U500 INSULIN IN SEVERELY INSULIN-RESISTANT PATIENTS WITH TYPE 2 DIABETES.每日总剂量对严重胰岛素抵抗的2型糖尿病患者使用人常规U500胰岛素两种剂量滴定方案的疗效、给药及安全性的影响
Endocr Pract. 2016 Jun;22(6):653-65. doi: 10.4158/EP15959.OR. Epub 2016 Jan 20.
10
As U-500 Insulin Safety Concerns Mount, It's Time to Rethink Safe Use of Strengths Above U-100.随着U-500胰岛素安全问题日益突出,是时候重新思考高于U-100强度胰岛素的安全使用问题了。
Home Healthc Now. 2015 Oct;33(9):501-2. doi: 10.1097/NHH.0000000000000292.