Ueda H, Ge M, Satoh M, Takagi H
Eur J Pharmacol. 1987 Apr 7;136(1):129-31.
Bicuculline methiodide, a GABAA antagonist produced potent analgesia in the tail pinch test when it was given intracisternally (i.c.) but not intrathecally (i.t.). The ED50 was 5 ng/mouse. This analgesia was antagonized by i.c. muscimol, a GABAA agonist. On the contrary, muscimol (i.t.) produced bicuculline-reversible analgesia. These findings suggest that brain GABA may transmit the nociceptive information while GABA in the spinal cord may inhibit it.
荷包牡丹碱甲碘化物，一种GABAA拮抗剂，当脑池内给药（i.c.）而非鞘内给药（i.t.）时，在夹尾试验中产生强效镇痛作用。半数有效剂量（ED50）为5纳克/只小鼠。这种镇痛作用被脑池内给予的GABAA激动剂蝇蕈醇所拮抗。相反，蝇蕈醇（鞘内给药）产生了可被荷包牡丹碱逆转的镇痛作用。这些发现表明，脑内的γ-氨基丁酸（GABA）可能传递伤害性信息，而脊髓中的GABA可能抑制该信息。
