Furst Meredith, Somogyi Marie B, Vrcek Ivan, Weir Edward, Shore John W
Long School of Medicine, University of Texas Health at San Antonio, San Antonio, Texas, U.S.A.
TOC Eye and Face, Austin, Texas, U.S.A.
Ophthalmic Plast Reconstr Surg. 2018 Nov/Dec;34(6):e204-e206. doi: 10.1097/IOP.0000000000001248.
Primary mucinous adenocarcinoma of the skin is an uncommon malignancy in clinical practice, but multicentric presentation of the malignancy is considered even more rare. In this case report, the authors present a 70-year-old woman with multicentric primary mucinous adenocarcinoma of the skin manifesting with 2 separate lesions located on the right eyelid and cheek. Lesion removal and immunohistochemical staining ruled out mucinous adenocarcinoma of the skin secondary to lung or thyroid carcinoma, however, was inconclusive for breast carcinoma. A negative breast examination and mammography determined the lesions were primary mucinous adenocarcinoma of the skin. Lesion removal resulted in a large defect, which was repaired using a tarsoconjunctival flap and right cheek rotational/advancement flap. Six months postoperatively, the patient's vision returned to baseline with excellent eyelid position and no evidence of local recurrence. Oral consent for the report and photographs was obtained from the patient and filed.
原发性皮肤黏液腺癌在临床实践中是一种罕见的恶性肿瘤，但该恶性肿瘤的多中心表现更为罕见。在本病例报告中，作者介绍了一名70岁女性，患有多中心原发性皮肤黏液腺癌，表现为位于右上眼睑和脸颊的2个独立病灶。病变切除及免疫组化染色排除了继发于肺癌或甲状腺癌的皮肤黏液腺癌，但对于乳腺癌的诊断尚无定论。乳房检查和乳房X光摄影结果为阴性，确定这些病变为原发性皮肤黏液腺癌。病变切除导致一个大的缺损，使用睑结膜瓣和右脸颊旋转/推进瓣进行修复。术后6个月，患者视力恢复至基线水平，眼睑位置良好，无局部复发迹象。已获得患者对报告及照片的口头同意并存档。
