Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, F-67000 Strasbourg, France.
Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; Centre National de la Recherche Scientifique, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
Neurosci Biobehav Rev. 2019 Jan;96:335-352. doi: 10.1016/j.neubiorev.2018.10.004. Epub 2018 Oct 23.
Parkinson's disease is a neurodegenerative disease leading to the loss of midbrain dopamine neurons. It is well known and characterized by motor symptoms that are secondary to the loss of dopamine innervation, but it is also accompanied by a range of various non-motor symptoms, including pain and psychiatric disorders such as anxiety and depression. These non-motor symptoms usually appear at early stages of the disease, sometimes even before the first motor symptoms, and have a dramatic impact on the quality of life of the patients. We review here the present state-of-the-art concerning pain, anxiety and depression-like parameters in animal models of Parkinson's disease.
帕金森病是一种神经退行性疾病，导致中脑多巴胺神经元丧失。它以运动症状为特征，这些症状继发于多巴胺神经支配的丧失，但也伴随着一系列各种非运动症状，包括疼痛和精神障碍，如焦虑和抑郁。这些非运动症状通常在疾病的早期出现，有时甚至在出现第一个运动症状之前，对患者的生活质量有重大影响。我们在这里回顾了帕金森病动物模型中疼痛、焦虑和抑郁样参数的最新研究进展。
