T Rague James, Varda Briony K, Wagner Andrew A, Lee Richard S
Department of Urology, Boston Medical Center, Boston, MA.
Department of Urology, Boston Children's Hospital, Boston, MA.
Urology. 2019 Feb;124:254-256. doi: 10.1016/j.urology.2018.10.030. Epub 2018 Oct 23.
Due to the rarity of the disease, adverse events related to ejaculatory function following the management of paratesticular rhabdomyosarcoma with multimodal therapy in adolescents are rarely discussed. Two patients, age 14 and 15 at time of diagnosis were treated with multimodal therapy with nerve-sparing retroperitoneal lymph node dissection, chemotherapy, and radiotherapy. Each developed ejaculatory dysfunction during the treatment period, which resolved 1 year after completion of all therapies. We sought to assess the role of each component of multimodal therapy on the observed side effect and the potential for delayed recovery of function after cessation of all therapies.
由于该疾病罕见,青少年睾丸旁横纹肌肉瘤采用多模式治疗后与射精功能相关的不良事件鲜有讨论。两名患者诊断时年龄分别为14岁和15岁,接受了保留神经的腹膜后淋巴结清扫术、化疗和放疗的多模式治疗。两人在治疗期间均出现射精功能障碍,在所有治疗结束1年后恢复。我们试图评估多模式治疗各组成部分对观察到的副作用的作用,以及停止所有治疗后功能延迟恢复的可能性。