人胎盘线粒体中腺嘌呤核苷酸交换减少。

Decreased exchange of adenine nucleotides in human placental mitochondria.

作者信息

Martínez F, Chávez E, Echegoyen S

出版信息

Int J Biochem. 1987;19(3):275-9. doi: 10.1016/0020-711x(87)90031-0.

Abstract

The purpose of this work was to study the exchange of adenine nucleotides in mitochondria isolated from human placenta tissue. The results indicate that ADP and ATP are translocated at a lower rate than those reported for rat liver mitochondria. It is proposed that the limited transport is due to the particular lipid composition of placental mitochondria membrane, which induces an arrest in membrane fluidity with the consequent restriction in adenine nucleotide translocase mobility.

摘要

这项工作的目的是研究从人胎盘组织分离的线粒体中腺嘌呤核苷酸的交换。结果表明，ADP和ATP的转运速率低于大鼠肝脏线粒体的报道速率。有人提出，转运受限是由于胎盘线粒体膜的特殊脂质组成，这导致膜流动性停滞，进而限制了腺嘌呤核苷酸转位酶的移动性。