Brick C, Atouf O, Ouadghiri S, Drissi Bourhanbour A, Bougar S, Yakhlef I, Essakalli M
Department of immunology and transfusion, CHU Ibn Sina Rabat, Rabat, Morocco.
Department of immunology and transfusion, CHU Ibn Sina Rabat, Rabat, Morocco; UPR of immunology, faculty of medicine and pharmacy, university Mohamed V Rabat, Rabat, Morocco.
Transfus Clin Biol. 2019 Nov;26(4):293-298. doi: 10.1016/j.tracli.2018.09.002. Epub 2018 Oct 6.
This study focuses on the search for a suitable related HLA-matched donor of haematopoietic stem cells in the context of allogeneic transplantation in Morocco. The aim of this work is to establish whether the related donor can meet graft needs in Moroccan patients.
429 families (429 recipients and 965 donors) benefited from HLA typing, using microlymphocytotoxicity, polymerase chain reaction-sequence specific primer and/or high-resolution polymerase chain reaction-specific sequence oligonucleotide.
The recipients and donors are mostly men over 18 years of age. In total, 86.8% of the recipients have between 1 and 3 donors who are 96% of the collaterals. Malignant haemopathies account for 54% of allograft indications. Benign haemopathies are more frequent than malignant in children, whereas the profile is reversed in adults. Fifty percent of recipients have an HLA identical donor in their siblings and 42% and HLA haplo identical donor. The HLA typing of the recipients and the donors reveals very large polymorphism of the population.
The related donor of haematopoietic stem cells represents an important source of grafts but will not be able to satisfy all the needs of Morocco. The creation of national unrelated voluntary donors will open up new possibilities for recipients who do not have a compatible donor within his relatives.
本研究聚焦于在摩洛哥异基因移植背景下寻找合适的人类白细胞抗原(HLA)匹配的造血干细胞相关供者。这项工作的目的是确定相关供者能否满足摩洛哥患者的移植需求。
429个家庭(429名受者和965名供者)接受了HLA分型,采用微量淋巴细胞毒性试验、聚合酶链反应-序列特异性引物法和/或高分辨率聚合酶链反应-特异性序列寡核苷酸法。
受者和供者大多为18岁以上男性。总体而言,86.8%的受者有1至3名供者,其中96%为旁系亲属。恶性血液病占所有移植指征的54%。良性血液病在儿童中比恶性血液病更常见,而在成人中情况则相反。50%的受者在其兄弟姐妹中有HLA全相合供者,42%有HLA单倍体相合供者。受者和供者的HLA分型显示出人群中非常大的多态性。
造血干细胞相关供者是移植的重要来源,但无法满足摩洛哥的所有需求。建立全国性非相关自愿供者库将为在亲属中没有合适供者的受者开辟新的可能性。