在 35 岁以下的女性中，卵母细胞的发育能力与卵巢储备无关。

Oocyte developmental competence is independent of ovarian reserve in women younger than 35 years.

机构信息

Clínica EUGIN, Travessera de les Corts 322, Barcelona 08029, Spain.

出版信息

Reprod Biomed Online. 2018 Dec;37(6):677-684. doi: 10.1016/j.rbmo.2018.09.007. Epub 2018 Oct 6.

DOI:10.1016/j.rbmo.2018.09.007

PMID:30366842

Abstract

RESEARCH QUESTION

Is higher antral follicle count (AFC) in healthy young women associated with higher oocyte developmental competence?

DESIGN

Retrospective study of 1985 first oocyte donation cycles, corresponding to 3210 fresh embryo transfers in oocyte recipients, conducted between January 2010 and May 2014.

RESULTS

Donors with higher AFC who underwent ovarian stimulation, produced both more cumulus-oocyte complexes (COC) (B coefficient = 0.47, 95% CI 0.41 to 0.53;P ≤ 0.001) and MII oocytes (B coefficient = 0.36, 95% CI 0.32 to 0.41;P ≤ 0.001) at linear regression analysis. Donors with low AFC had a higher risk of cancellation (OR 4.79, 95% CI 2.99 to 7.69;P < 0.001) or obtaining fewer than four metaphase II (MII) at ovum retrieval (OR 3.87, 95% CI 2.38 to 6.27;P < 0.001). No association was found between AFC and biochemical (OR 1.13, 95% CI 0.93 to 1.36), clinical (OR 1.05, 95% CI 0.87 to 1.28), ongoing pregnancy (OR 1.00, 95%, CI 0.82 to 1.21) or live birth rates (OR 0.97, 95% CI 0.8 to 1.19), when at least four MII were obtained at ovum retrieval.

CONCLUSIONS

AFC does not relate to the developmental competence of oocytes in women younger than 35 years.

摘要

研究问题

健康年轻女性的窦卵泡计数（AFC）较高是否与卵母细胞发育能力较高有关？

设计

这是一项回顾性研究，纳入了 2010 年 1 月至 2014 年 5 月期间进行的 1985 例首次卵母细胞捐赠周期中的 3210 例新鲜胚胎移植，共涉及卵母细胞受体。

结果

在线性回归分析中，接受卵巢刺激的 AFC 较高的供者产生的卵丘-卵母细胞复合物（COC）（B 系数=0.47，95%置信区间 0.41 至 0.53；P≤0.001）和 MII 卵母细胞（B 系数=0.36，95%置信区间 0.32 至 0.41；P≤0.001）更多。AFC 较低的供者取消的风险更高（OR 4.79，95%置信区间 2.99 至 7.69；P<0.001），或在取卵时获得的少于 4 个 MII 卵母细胞（OR 3.87，95%置信区间 2.38 至 6.27；P<0.001）。在获得至少 4 个 MII 卵母细胞时，AFC 与生化妊娠率（OR 1.13，95%置信区间 0.93 至 1.36）、临床妊娠率（OR 1.05，95%置信区间 0.87 至 1.28）、持续妊娠率（OR 1.00，95%置信区间 0.82 至 1.21）或活产率（OR 0.97，95%置信区间 0.8 至 1.19）之间无相关性。