高血压和肥胖症使β-淀粉样蛋白与中年认知能力下降之间的关系变得复杂。
Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife.
机构信息
Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
出版信息
Alzheimers Dement. 2019 Mar;15(3):418-428. doi: 10.1016/j.jalz.2018.09.008. Epub 2018 Oct 25.
BACKGROUND
This study tested if central obesity, hypertension, or depressive symptoms moderated the relationship between β-amyloid (Aβ) and longitudinal cognitive performance in late middle-aged adults enriched for Alzheimer's disease (AD) risk.
METHODS
Participants (n = 207; ages = 40-70 years; 73% parental AD) in the Wisconsin Registry for Alzheimer's Prevention study completed 3+ neuropsychological evaluations and a [C]PiB positron emission tomography scan or lumbar puncture. Linear mixed-effects regression models tested interactions of risk factor × Aβ × visit age on longitudinal Verbal Learning & Memory and Speed & Flexibility factor scores.
RESULTS
The relationship between Aβ and Verbal Learning & Memory decline was moderated by hypertension (χ = 3.85, P = .04) and obesity (χ = 6.12, P = .01); those with both elevated Aβ and the risk factor declined at faster rates than those with only elevated Aβ or elevated risk factors.
CONCLUSION
In this cohort, hypertension and obesity moderated the relationship between Aβ and cognitive decline.
背景
本研究旨在检验中心性肥胖、高血压或抑郁症状是否调节了β-淀粉样蛋白（Aβ）与阿尔茨海默病（AD）风险人群中老年中期认知表现的纵向关系。
方法
威斯康星州 AD 预防研究注册中心的参与者（n=207；年龄为 40-70 岁；73%的父母患有 AD）完成了 3 次以上的神经心理学评估和 [C]PiB 正电子发射断层扫描或腰椎穿刺。线性混合效应回归模型检验了危险因素×Aβ×访视年龄对纵向言语学习和记忆及速度和灵活性因子评分的交互作用。
结果
Aβ与言语学习和记忆下降的关系受到高血压（χ²=3.85，P=.04）和肥胖（χ²=6.12，P=.01）的调节；与仅存在高 Aβ或高风险因素的人相比，同时存在高 Aβ和风险因素的人的下降速度更快。
结论
在本队列中，高血压和肥胖症调节了 Aβ与认知下降之间的关系。
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