Fodor Gergely H, Balogh Adam L, Sudy Roberta, Ivankovits-Kiss Orsolya, Babik Barna, Petak Ferenc
Department of Medical Physics and Informatics, University of Szeged, 9, Koranyi fasor, H6720, Szeged, Hungary.
Department of Medical Physics and Informatics, University of Szeged, 9, Koranyi fasor, H6720, Szeged, Hungary; Department of Anesthesiology and Intensive Therapy, University of Szeged, 6, Semmelweis street H6725, Szeged, Hungary.
Respir Physiol Neurobiol. 2019 Jan;259:156-161. doi: 10.1016/j.resp.2018.10.006. Epub 2018 Oct 24.
To clarify the potential of dopamine to alter airway tone in the presence of different bronchoconstrictor stimuli, changes in airway function following dopamine administrations were characterized when the bronchial tone was elevated by stimulating the histaminic or cholinergic pathway. Airway resistance, tissue damping and tissue elastance were measured in anesthetized mechanically ventilated rabbits under baseline conditions, during steady-state bronchoconstriction induced by methacholine or histamine, and following intravenous dopamine (5 and 15 μg/kg/min). Bronchoconstriction induced by methacholine and histamine was significantly ameliorated by dopamine (14.8 ± 2.9% and 14.9 ± 2.9%; p < 0.05 for both), with no difference between the mode of stimuli. Dopamine had no effect on the tissue mechanics. These findings indicate that dopamine relaxes the elevated airway smooth muscle tone without affecting the lung periphery, and this effect is independent of the mode of constrictor stimuli. This profile of dopamine suggests its ability to treat effectively cholinergic and histaminergic bronchoconstriction, besides its positive inotropic effects on the myocardial contractility.
为了阐明在存在不同支气管收缩刺激时多巴胺改变气道张力的潜力，当通过刺激组胺能或胆碱能途径使支气管张力升高时，对给予多巴胺后气道功能的变化进行了表征。在麻醉的机械通气兔中，在基线条件下、在由乙酰甲胆碱或组胺诱导的稳态支气管收缩期间以及静脉注射多巴胺（5和15μg/kg/min）后，测量气道阻力、组织阻尼和组织弹性。多巴胺可显著改善由乙酰甲胆碱和组胺诱导的支气管收缩（分别为14.8±2.9%和14.9±2.9%；两者p<0.05），刺激方式之间无差异。多巴胺对组织力学无影响。这些发现表明，多巴胺可松弛升高的气道平滑肌张力而不影响肺外周，且这种作用与收缩刺激方式无关。多巴胺的这种特性表明，除了对心肌收缩力有正性肌力作用外，它还能够有效治疗胆碱能和组胺能支气管收缩。
